Clinical Utility of Multi-Energy Spectral Photon-Counting Computed Tomography in Crystal Arthritis.

Détails

ID Serval
serval:BIB_3F0AF9F6D525
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical Utility of Multi-Energy Spectral Photon-Counting Computed Tomography in Crystal Arthritis.
Périodique
Arthritis & rheumatology
Auteur(s)
Stamp L.K., Anderson N.G., Becce F., Rajeswari M., Polson M., Guyen O., Viry A., Choi C., Kirkbride T.E., Raja A.Y.
ISSN
2326-5205 (Electronic)
ISSN-L
2326-5191
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
71
Numéro
7
Pages
1158-1162
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To determine whether novel multi-energy spectral photon-counting computed tomography (SPCCT) imaging can detect and differentiate between monosodium urate (MSU), calcium pyrophosphate (CPP), and hydroxyapatite (HA) crystal deposits ex vivo.
A finger with a subcutaneous gouty tophus and a calcified knee meniscus excised at the time of surgery were obtained. The finger was imaged using plain x-ray, dual-energy CT (DECT), and multi-energy SPCCT. Plain x-ray and multi-energy SPCCT images of the meniscus were acquired. For validation purposes, samples of the crystals were obtained from the tophus and meniscus, and examined by polarized light microscopy and/or x-ray diffraction. As further validation, synthetic crystal suspensions of MSU, CPP, and HA were scanned using multi-energy SPCCT.
Plain x-ray of the gouty finger revealed bone erosions with overhanging edges. DECT and multi-energy SPCCT both showed MSU crystal deposits; SPCCT was able to show finer detail. Plain x-ray of the calcified meniscus showed chondrocalcinosis consistent with CPP, while SPCCT showed and differentiated CPP and HA.
Multi-energy SPCCT can not only detect, differentiate, and quantify MSU crystal deposits in a gouty finger ex vivo, but also specifically detect, identify, and quantify CPP within an osteoarthritic meniscus, and distinguish them from HA crystal deposits. There is potential for multi-energy SPCCT to become useful in the diagnosis of crystal arthropathies.
Mots-clé
calcium hydroxyapatite, calcium pyrophosphate, crystals, imaging, monosodium urate, multi-energy spectral photon-counting CT
Pubmed
Web of science
Création de la notice
25/03/2019 9:25
Dernière modification de la notice
21/08/2019 6:34
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