Neutrophils enhance early Trypanosoma brucei infection onset.

Détails

Ressource 1Télécharger: s41598-018-29527-y.pdf (2070.92 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_3F0045057EE4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neutrophils enhance early Trypanosoma brucei infection onset.
Périodique
Scientific Reports
Auteur(s)
Caljon G., Mabille D., Stijlemans B., De Trez C., Mazzone M., Tacchini-Cottier F., Malissen M., A Van Ginderachter J., Magez S., De Baetselier P., Van Den Abbeele J.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
11203
Langue
anglais
Résumé
In this study, Trypanosoma brucei was naturally transmitted to mice through the bites of infected Glossina morsitans tsetse flies. Neutrophils were recruited rapidly to the bite site, whereas monocytes were attracted more gradually. Expression of inflammatory cytokines (il1b, il6), il10 and neutrophil chemokines (cxcl1, cxcl5) was transiently up-regulated at the site of parasite inoculation. Then, a second influx of neutrophils occurred that coincided with the previously described parasite retention and expansion in the ear dermis. Congenital and experimental neutropenia models, combined with bioluminescent imaging, indicate that neutrophils do not significantly contribute to dermal parasite control and elicit higher systemic parasitemia levels during the infection onset. Engulfment of parasites by neutrophils in the skin was rarely observed and was restricted to parasites with reduced motility/viability, whereas live parasites escaped phagocytosis. To our knowledge, this study represents the first description of a trypanosome infection promoting role of early innate immunological reactions following an infective tsetse fly bite. Our data indicate that the trypanosome is not hindered in its early development and benefits from the host innate responses with the neutrophils being important regulators of the early infection, as already demonstrated for the sand fly transmitted Leishmania parasite.
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/07/2018 11:53
Dernière modification de la notice
20/08/2019 14:36
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