The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.

Détails

ID Serval
serval:BIB_3EC9D9C38883
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
Périodique
Pharmaceutica Acta Helvetiae
Auteur(s)
Cotecchia S., Rossier O., Fanelli F., Leonardi A., De Benedetti P.G.
ISSN
0031-6865 (Print)
ISSN-L
0031-6865
Statut éditorial
Publié
Date de publication
2000
Volume
74
Numéro
2-3
Pages
173-179
Langue
anglais
Résumé
In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
Mots-clé
Animals, Humans, Receptors, Adrenergic, alpha-1/chemistry, Receptors, Adrenergic, alpha-1/drug effects
Pubmed
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 13:35
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