Article: article from journal or magazin.
Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor.
Journal of Neural Transmission
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Sulfur containing amino acids such as homocysteic acid (HCA), cysteinsulfinic acid, homocysteinsulfinic acid are released by depolarization of slices from various rat brain regions in a Ca++-dependent manner. L-HCA excites caudate neurons through their N-methyl-D-aspartic acid (NMDA) receptor and potentiates their cortically evoked excitatory postsynaptic potentials. 35S-methionine can label the releasable pool of HCA, and thus appears as a precursor of HCA. Thus HCA is a transmitter candidate which acts predominantly on the NMDA receptor.
Animals, Aspartic Acid/analogs & derivatives, Aspartic Acid/pharmacology, Brain/metabolism, Chromatography, High Pressure Liquid, Cysteine/analogs & derivatives, Cysteine/metabolism, Homocysteine/analogs & derivatives, Homocysteine/metabolism, N-Methylaspartate, Neurotransmitter Agents/metabolism, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter/physiology, Tissue Distribution
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