High-mobility group box-1 protein determination in postmortem samples.

Détails

ID Serval
serval:BIB_3EB6F85AA315
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
High-mobility group box-1 protein determination in postmortem samples.
Périodique
Forensic Science International
Auteur(s)
Palmiere C., Augsburger M., Mangin P.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
239
Pages
103-106
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish ; PDF: Technical notes
Résumé
The aims of this study were to assess whether high-mobility group box-1 protein can be determined in biological fluids collected during autopsy and evaluate the diagnostic potential of high-mobility group box-1 protein in identifying sepsis-related deaths. High-mobility group box-1 protein was measured in serum collected during hospitalization as well as in undiluted and diluted postmortem serum and pericardial fluid collected during autopsy in a group of sepsis-related deaths and control cases with noninfectious causes of death. Inclusion criteria consisted of full biological sample availability and postmortem interval not exceeding 6h. The preliminary results indicate that high-mobility group box-1 protein levels markedly increase after death. Concentrations beyond the upper limit of the calibration curve were obtained in undiluted postmortem serum in septic and traumatic control cases. In pericardial fluid, concentrations beyond the upper limit of the calibration curve were found in all cases. These findings suggest that the diagnostic potential of high-mobility group box-1 protein in the postmortem setting is extremely limited due to molecule release into the bloodstream after death, rendering antemortem levels difficult or impossible to estimate even after sample dilution.
Pubmed
Web of science
Création de la notice
06/06/2014 17:29
Dernière modification de la notice
20/08/2019 14:35
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