Comparison of the reactogenicity and immunogenicity of a two injection combined high-dose hepatitis A and hepatitis B vaccine to those of Twinrix

Details

Serval ID
serval:BIB_3E8A92DE848D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of the reactogenicity and immunogenicity of a two injection combined high-dose hepatitis A and hepatitis B vaccine to those of Twinrix
Journal
Vaccine
Author(s)
Greub  G., Genton  B., Safary  A., Thoelen  S., Frei  P. C.
ISSN
0264-410X (Print)
Publication state
Published
Issued date
12/2000
Volume
19
Number
9-10
Pages
1113-7
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Dec 8
Abstract
Twinrix (SmithKline Beecham Biologicals) is a combined hepatitis A and B vaccine licensed with a three-dose schedule. A two-dose combined hepatitis A and B vaccine would facilitate immunisation programs. In this prospective study, 100 healthy adults, aged between 18 and 40, were enrolled. A first group of 50 was given a high-dose vaccine at month 0 and 6. A second group of 50 received Twinrix at month 0, 1 and 6.The reactogenicity was assessed after each vaccine dose. There were no severe local adverse events. Seven severe systemic reactions occurred, of which five were fatigue, one was headache and one consist in gastrointestinal symptoms. They all resolved during the 4-day follow-up period. One serious general adverse event was reported, but was clearly unrelated to the vaccine. Thus, both vaccines were well tolerated.The immunogenicity was evaluated by testing for anti-HBs and anti-HAV antibodies. Seroconversion rates and geometric mean titres (GMTs) were compared. At month 7, the anti-HAV GMTs were higher in the high-dose group than in the Twinrix group and, inversely, the anti-HBs GMTs were slightly higher in the Twinrix group than in the high-dose group. At month 7, all subjects in both groups were positive for anti-HAV. All subjects in the high-dose group and 97.6% subjects in the Twinrix group had seroconverted for anti-HBs. Therefore, it can be concluded that with two injections of the high-dose hepatitis A and B vaccine, 6 months apart, a similar immune response can be obtained as induced with three doses of Twinrix at months 0, 1 and 6.
Keywords
Adolescent Adult Female Hepatitis A Antibodies Hepatitis A Vaccines/*administration & dosage Hepatitis Antibodies/blood Hepatitis B Antibodies/blood Hepatitis B Vaccines/*administration & dosage Humans Injections Male Pilot Projects Prospective Studies Vaccination Vaccines, Combined/immunology
Pubmed
Web of science
Create date
28/01/2008 11:49
Last modification date
20/08/2019 13:35
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