Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies.

Détails

ID Serval
serval:BIB_3E74CBFB8328
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies.
Périodique
Cancer cell
Auteur(s)
Mina M., Raynaud F., Tavernari D., Battistello E., Sungalee S., Saghafinia S., Laessle T., Sanchez-Vega F., Schultz N., Oricchio E., Ciriello G.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
14/08/2017
Peer-reviewed
Oui
Volume
32
Numéro
2
Pages
155-168.e6
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the nature of these evolutionary dependencies and their impact remain unclear. Here, we designed SELECT, an algorithmic approach to systematically identify evolutionary dependencies from alteration patterns. By analyzing 6,456 genomes from multiple tumor types, we constructed a map of oncogenic dependencies associated with cellular pathways, transcriptional readouts, and therapeutic response. Finally, modeling of cancer evolution shows that alteration dependencies emerge only under conditional selection. These results provide a framework for the design of strategies to predict cancer progression and therapeutic response.

Mots-clé
cancer evolution, conditional selection, interdependent therapeutic response, oncogenic dependencies, selected events
Pubmed
Web of science
Création de la notice
08/08/2017 11:20
Dernière modification de la notice
21/08/2019 5:34
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