Association of endogenous testosterone with subclinical atherosclerosis in men: the multi-ethnic study of atherosclerosis.

Details

Serval ID
serval:BIB_3E248804E15F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Association of endogenous testosterone with subclinical atherosclerosis in men: the multi-ethnic study of atherosclerosis.
Journal
Clinical endocrinology
Author(s)
Khazai B., Golden S.H., Colangelo L.A., Swerdloff R., Wang C., Honoris L., Gapstur S.M., Ouyang P., Cushman M., Li D., Kopp P., Vaidya D., Liu K., Dobs A., Budoff M.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Publication state
Published
Issued date
05/2016
Peer-reviewed
Oui
Volume
84
Number
5
Pages
700-707
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Whether endogenous sex hormones play a role in cardiovascular disease (CVD) risk in men is unclear. Few studies have examined associations of sex hormones with atherosclerosis measured by coronary artery calcium score (CACS) and carotid intima-media thickness (cIMT). We evaluated the association of testosterone (T) and other sex hormones with CACS and cIMT.
Using the large multi-ethnic cohort of 3164 men without known CVD in the Multi-Ethnic Study of Atherosclerosis (MESA), cross-sectional associations of tertiles of endogenous sex hormones with CACS and cIMT were analysed.
In regard to CAC, there was a significant negative trend (P-trend = 0·02) for CACS>0 over tertiles of free T (FT) with RRs (95% CI) for the lowest to highest tertiles. There was also a marginally significant positive trend (P-trend = 0·06) for CACS>0 over tertiles of sex hormone-binding globulin (SHBG) with RRs for the lowest to highest tertiles. There were no significant associations with CACS >0 for tertiles of TT (Total T), bioavailable T (BT), oestradiol (E2) and dehydroepiandrosterone (DHEA). There was significantly higher log CACS after adjustment for CVD risk factors for lower TT levels, compared to higher levels, using 9·54 and 10·4 nmol/l as cut-off points. In regard to cIMT, there was a significant positive trend (P = 0·003) in mean cIMT over the tertiles of BT, but not for TT, FT, E2, DHEA and SHBG. There was significantly lower cIMT after adjustment for CVD risk factors for lower TT levels compared to higher levels.
In a population of male subjects with no known CVD, lower FT is associated with higher RR of CACS>0 and lower TT is associated with higher log CACS. Lower BT and TT are associated with lower cIMT. While these findings support the positive correlation between low T and coronary atherosclerosis, the opposite findings on cIMT warrant further evaluation.
Keywords
African Americans/statistics & numerical data, Aged, Aged, 80 and over, Asian Americans/statistics & numerical data, Atherosclerosis/blood, Atherosclerosis/ethnology, Atherosclerosis/pathology, Calcium/metabolism, Carotid Intima-Media Thickness, Coronary Vessels/metabolism, Dehydroepiandrosterone/blood, Estradiol/blood, European Continental Ancestry Group/statistics & numerical data, Hispanic Americans/statistics & numerical data, Humans, Male, Middle Aged, Multivariate Analysis, Prospective Studies, Risk Assessment/methods, Risk Assessment/statistics & numerical data, Risk Factors, Sex Hormone-Binding Globulin/analysis, Testosterone/blood, United States
Pubmed
Web of science
Create date
27/12/2020 13:59
Last modification date
28/12/2020 6:26
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