Comparison of direct and indirect alcohol markers with PEth in blood and urine in alcohol dependent inpatients during detoxication.

Détails

ID Serval
serval:BIB_3DF7E3D4F9CC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of direct and indirect alcohol markers with PEth in blood and urine in alcohol dependent inpatients during detoxication.
Périodique
International Journal of Legal Medicine
Auteur(s)
Winkler M., Skopp G., Alt A., Miltner E., Jochum T., Daenhardt C., Sporkert F., Gnann H., Weinmann W., Thierauf A.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
2013
Volume
127
Numéro
4
Pages
761-768
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The importance of direct and indirect alcohol markers to evaluate alcohol consumption in clinical and forensic settings is increasingly recognized. While some markers are used to prove abstinence from ethanol, other markers are suitable for detection of alcohol misuse. Phosphatidyl ethanol (PEth) is ranked among the latter. There is only little information about the correlation between PEth and other currently used markers (ethyl glucuronide, ethyl sulfate, carbohydrate deficient transferrin, gamma-glutamyl transpeptidase, and methanol) and about their decline during detoxification. To get more information, 18 alcohol-dependent patients in withdrawal therapy were monitored for these parameters in blood and urine for up to 19 days. There was no correlation between the different markers. PEth showed a rapid decrease at the beginning of the intervention, a slow decline after the first few days, and could still be detected after 19 days of abstinence from ethanol.
Pubmed
Web of science
Création de la notice
11/08/2013 8:34
Dernière modification de la notice
20/08/2019 13:34
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