Rapport sur le traitement conservateur des melanomes de l'uvee a la clinique ophtalmologique universitaire de Lausanne. [Report on the conservative treatment of melanoma of the uvea at the Lausanne University Ophthalmologic Clinic]

Details

Serval ID
serval:BIB_3DB6F349C380
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rapport sur le traitement conservateur des melanomes de l'uvee a la clinique ophtalmologique universitaire de Lausanne. [Report on the conservative treatment of melanoma of the uvea at the Lausanne University Ophthalmologic Clinic]
Journal
Klinische Monatsblatter fur Augenheilkunde
Author(s)
Zografos  L., Gailloud  C., Perret  C., Uffer  S., Raimondi  S., Chamot  L., Carrel  S., Greiner  R.
ISSN
0023-2165 (Print)
Publication state
Published
Issued date
05/1988
Volume
192
Number
5
Pages
572-8
Notes
Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
A great number of techniques are currently available for the conservative treatment of uveal melanomas: ocular applicators emitting gamma rays 60Co, 125I) or high-energy beta rays (106Ru/106Rh), light photocoagulation, surgical excision, and accelerated proton beam irradiation. Life expectancy following conservative treatment is equal to or better than that following enucleation. This is demonstrated by nonrandomized comparative studies, and by the authors' own long-term results following the conservative treatment of melanomas by 60Co applicators: mortality due to metastases of small melanomas was 3% (V = smaller than 10 x 10 x 3 mm), with medium-size melanomas it was 12% (V = 10 x 10 x 3-15 x 15 x 5 mm), and with large melanomas 21% (V = larger than 15 x 15 x 5 mm). Accelerated proton beam irradiation of uveal melanomas is currently the method of choice for the conservative treatment of uveal melanomas. The sharp boundaries of the irradiated zone, the uniformly distributed irradiation dose, and beam-splitting are the main advantages of this technique. During the last three years, 310 cases of uveal melanoma have been treated in Switzerland with an accelerated proton beam. Of these, 214 were followed up for more than one year. Eight patients (3.9%) died of metastases. Visual acuity was identical or superior to initial visual acuity in 60.3% of the cases, while 39.6% exhibited a deterioration of vision or a functional loss. Favorable results achieved by conservative treatment of uveal melanomas considerably limited the indications for enucleation, which is now only performed in exceptional situations.
Keywords
Brachytherapy/*methods Follow-Up Studies Humans Laser Surgery Melanoma/*radiotherapy/surgery Radiotherapy Dosage Uveal Neoplasms/*radiotherapy/surgery
Pubmed
Web of science
Create date
28/01/2008 13:09
Last modification date
20/08/2019 13:34
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