Inter-organ communication: a gatekeeper for metabolic health.

Détails

ID Serval
serval:BIB_3D85056E88C8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Inter-organ communication: a gatekeeper for metabolic health.
Périodique
EMBO reports
Auteur(s)
Castillo-Armengol J., Fajas L., Lopez-Mejia I.C.
ISSN
1469-3178 (Electronic)
ISSN-L
1469-221X
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
20
Numéro
9
Pages
e47903
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Multidirectional interactions between metabolic organs in the periphery and the central nervous system have evolved concomitantly with multicellular organisms to maintain whole-body energy homeostasis and ensure the organism's adaptation to external cues. These interactions are altered in pathological conditions such as obesity and type 2 diabetes. Bioactive peptides and proteins, such as hormones and cytokines, produced by both peripheral organs and the central nervous system, are key messengers in this inter-organ communication. Despite the early discovery of the first hormones more than 100 years ago, recent studies taking advantage of novel technologies have shed light on the multiple ways used by cells in the body to communicate and maintain energy balance. This review briefly summarizes well-established concepts and focuses on recent advances describing how specific proteins and peptides mediate the crosstalk between gut, brain, and other peripheral metabolic organs in order to maintain energy homeostasis. Additionally, this review outlines how the improved knowledge about these inter-organ networks is helping us to redefine therapeutic strategies in an effort to promote healthy living and fight metabolic disorders and other diseases.
Mots-clé
energy homeostasis, inter-organ communication, metabolism, obesity
Pubmed
Open Access
Oui
Création de la notice
31/08/2019 0:14
Dernière modification de la notice
24/01/2020 7:26
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