Pulmonary Sarcoid-like Granulomatosis after Multiple Vaccinations of a Long-term Surviving Patient with Metastatic Melanoma.

Détails

ID Serval
serval:BIB_3CFC56A8F483
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Pulmonary Sarcoid-like Granulomatosis after Multiple Vaccinations of a Long-term Surviving Patient with Metastatic Melanoma.
Périodique
Cancer Immunology Research
Auteur(s)
Bordry N., Costa-Nunes C.M., Cagnon L., Gannon P.O., Abed-Maillard S., Baumgaertner P., Murray T., Letovanec I., Lazor R., Bouchaab H., Rufer N., Romano E., Michielin O., Speiser D.E.
ISSN
2326-6066; 2326-6074 (Electronic)
Statut éditorial
Publié
Date de publication
2014
Volume
2
Numéro
12
Pages
1148-1153
Langue
anglais
Notes
Publication types: Journal Article, Here, we present a case report
Résumé
Autoimmune side effects are frequent in patients with cancer treated with immune checkpoint-targeting antibodies, but are rare with cancer vaccines. Here, we present a case report on a patient with metastatic melanoma who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinations with peptides and CpG. Despite multiple metastases, including one lesion in the brain, the patient is alive and well more than 13 years after the diagnosis of metastatic disease. The strongly activated tumor-specific CD8(+) T cells showed robust long-term memory and effector functions. It is possible that long-term survival and adverse autoimmune events may become more common for vaccines inducing robust anticancer immune responses as were present in this patient. Cancer Immunol Res; 2(12); 1148-53. ©2014 AACR.
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/10/2014 14:22
Dernière modification de la notice
20/08/2019 14:33
Données d'usage