In normal men, free fatty acids reduce peripheral but not splanchnic glucose uptake.

Details

Serval ID
serval:BIB_3CEECF61B5BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In normal men, free fatty acids reduce peripheral but not splanchnic glucose uptake.
Journal
Diabetes
Author(s)
Rigalleau V., Binnert C., Minehira K., Stefanoni N., Schneiter P., Henchoz E., Matzinger O., Cayeux C., Jéquier E., Tappy L.
ISSN
0012-1797 (Print)
ISSN-L
0012-1797
Publication state
Published
Issued date
2001
Volume
50
Number
4
Pages
727-732
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Raising plasma free fatty acid (FFA) levels reduces muscle glucose uptake, but the effect of FFAs on splanchnic glucose uptake, total glucose output, and glucose cycling may also be critical to producing lipid-induced glucose intolerance. In eight normal volunteers, we measured glucose turnover and cycling rates ([2H7]glucose infusion) during a moderately hyperglycemic (7.7 mmol/l) hyperinsulinemic clamp, before and after ingestion of a labeled (dideuterated) oral glucose load (700 mg/kg). Each test was performed twice, with either a lipid or a saline infusion; four subjects also had a third test with a glycerol infusion. As shown by similar rates of exogenous glucose appearance, the lipid infusion did not reduce first-pass splanchnic glucose uptake (saline 1.48+/-0.18, lipid 1.69+/-0.17, and glycerol 1.88+/-0.17 mmol/kg per 180 min; NS), but it reduced peripheral glucose uptake by 40% (P < 0.01 vs. both saline and glycerol infusions). Before oral ingestion of glucose, total glucose output was similarly increased by the lipid and glycerol infusions. Total glucose output was significantly increased by FFAs after oral ingestion of glucose (saline 3.68+/-1.15, glycerol 3.68+/-1.70, and lipid 7.92+/-0.88 micromol x kg(-1) x min(-1); P < 0.01 vs. saline and P < 0.05 vs. glycerol). The glucose cycling rate was approximately 2.7 micromol x kg(-1) x min(-1) with the three infusions and tended to decrease all along the lipid infusion, which argues against a stimulation of glucose-6-phosphatase by FFAs. It is concluded that in situations of moderate hyperinsulinemia-hyperglycemia, FFAs reduce peripheral but not splanchnic glucose uptake. Total glucose output is increased by FFAs, by a mechanism that does not seem to involve stimulation of glucose-6-phosphatase.
Keywords
Adult, Fats/pharmacology, Fatty Acids, Nonesterified/blood, Fatty Acids, Nonesterified/pharmacology, Glucose/pharmacokinetics, Glycerol/pharmacology, Hormones/blood, Humans, Male, Muscle, Skeletal/metabolism, Reference Values, Tissue Distribution, Viscera/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:36
Last modification date
20/08/2019 13:33
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