Radiosurgery for treatment of brain metastases: estimation of patient eligibility using three stratification systems.

Details

Serval ID
serval:BIB_3CD58B61F062
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Radiosurgery for treatment of brain metastases: estimation of patient eligibility using three stratification systems.
Journal
International Journal of Radiation Oncology, Biology, Physics
Author(s)
Lorenzoni J., Devriendt D., Massager N., David P., Ruíz S., Vanderlinden B., Van Houtte P., Brotchi J., Levivier M.
ISSN
0360-3016 (Print)
ISSN-L
0360-3016
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
60
Number
1
Pages
218-224
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
PURPOSE: To compare three patient stratification systems predicting survival: recursive partitioning analysis (RPA), score index for radiosurgery in brain metastases (SIR), and a proposed basic score for brain metastases (BS-BM).
METHODS AND MATERIALS: We analyzed the outcome of 110 patients treated with Leksell Gamma Knife radiosurgery between December 1999 and January 2003. The BS-BM was calculated by evaluating three main prognostic factors: Karnofsky performance status, primary tumor control, and presence of extracranial metastases.
RESULTS: The median survival was 27.6 months for RPA Class I, 10.7 months for RPA Class II, and 2.8 months for RPA Class III (p <0.0001). Using the SIR, the median survival was 27.7, 10.8, 4.6, and 2.4 months for a score of 8-10, 5-7, 4, and 0-3, respectively (p <0.0001). The median survival was undefined in patients with a BS-BM of 3 (55% at 32 months) and was 13.1 months for a BS-BM of 2, 3.3 months for a BS-BM of 1, and 1.9 months for a BS-BM of 0 (p <0.0001). The backward elimination model in multivariate Cox analysis identified SIR and BS-BM as the only two variables significantly associated with survival (p = 0.031 and p = 0.043, respectively).
CONCLUSION: SIR and BS-BM were the most accurate for estimating survival. They were specific enough to identify patients with short survival (SIR 0-3 and BS-BM 0). Because of it simplicity, BS-BM is easier to use.
Keywords
Adult, Aged, Aged, 80 and over, Analysis of Variance, Brain Neoplasms/mortality, Brain Neoplasms/secondary, Disease Progression, Female, Humans, Male, Middle Aged, Radiosurgery, Radiotherapy Dosage, Regression Analysis, Survival Analysis, Treatment Outcome
Pubmed
Web of science
Create date
20/01/2008 17:35
Last modification date
20/08/2019 13:33
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