Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine.
Details
Serval ID
serval:BIB_3C73051933C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine.
Journal
Critical care
Working group(s)
Working Group on Gastrointestinal Function within the Section of Metabolism, Endocrinology and Nutrition (MEN Section) of ESICM
Contributor(s)
Reintam Blaser A., Preiser J.C., Fruhwald S., Wilmer A., Wernerman J., Benstoem C., Casaer M.P., Starkopf J., van Zanten A., Rooyackers O., Jakob S.M., Loudet C.I., Bear D.E., Elke G., Kott M., Lautenschläger I., Schäper J., Gunst J., Stoppe C., Nobile L., Fuhrmann V., Berger M.M., Oudemans-van Straaten H.M., Arabi Y.M., Dean A.M., Amrein K., Besch G., Belazi Nery de Souza Campos B., De Waele E., Fraipont V., Grau T., Gundogan K., Heidegger C., Hiesmayr M., Ichai C., Juan-Díaz M., Kobke-Jacobsen K., Koutsoukou V., Laube M., Montejo González J.C., Puthucheary Z., Rousseau A.F., Singer P., Stapel S.N., Tekguc H., Torruco-Sotelo C.
ISSN
1466-609X (Electronic)
ISSN-L
1364-8535
Publication state
Published
Issued date
15/05/2020
Peer-reviewed
Oui
Volume
24
Number
1
Pages
224
Language
english
Notes
Publication types: Journal Article ; Systematic Review
Publication Status: epublish
Publication Status: epublish
Abstract
Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We aimed to develop a research agenda for GI dysfunction for future research. We systematically reviewed the current knowledge on a broad range of subtopics from a specific viewpoint of GI dysfunction, highlighting the remaining areas of uncertainty and suggesting future studies.
This systematic scoping review and research agenda was conducted following successive steps: (1) identify clinically important subtopics within the field of GI function which warrant further research; (2) systematically review the literature for each subtopic using PubMed, CENTRAL and Cochrane Database of Systematic Reviews; (3) summarize evidence for each subtopic; (4) identify areas of uncertainty; (5) formulate and refine study proposals that address these subtopics; and (6) prioritize study proposals via sequential voting rounds.
Five major themes were identified: (1) monitoring, (2) associations between GI function and outcome, (3) GI function and nutrition, (4) management of GI dysfunction and (5) pathophysiological mechanisms. Searches on 17 subtopics were performed and evidence summarized. Several areas of uncertainty were identified, six of them needing consensus process. Study proposals ranked among the first ten included: prevention and management of diarrhoea; management of upper and lower feeding intolerance, including indications for post-pyloric feeding and opioid antagonists; acute gastrointestinal injury grading as a bedside tool; the role of intra-abdominal hypertension in the development and monitoring of GI dysfunction and in the development of non-occlusive mesenteric ischaemia; and the effect of proton pump inhibitors on the microbiome in critical illness.
Current evidence on GI dysfunction is scarce, partially due to the lack of precise definitions. The use of core sets of monitoring and outcomes are required to improve the consistency of future studies. We propose several areas for consensus process and outline future study projects.
This systematic scoping review and research agenda was conducted following successive steps: (1) identify clinically important subtopics within the field of GI function which warrant further research; (2) systematically review the literature for each subtopic using PubMed, CENTRAL and Cochrane Database of Systematic Reviews; (3) summarize evidence for each subtopic; (4) identify areas of uncertainty; (5) formulate and refine study proposals that address these subtopics; and (6) prioritize study proposals via sequential voting rounds.
Five major themes were identified: (1) monitoring, (2) associations between GI function and outcome, (3) GI function and nutrition, (4) management of GI dysfunction and (5) pathophysiological mechanisms. Searches on 17 subtopics were performed and evidence summarized. Several areas of uncertainty were identified, six of them needing consensus process. Study proposals ranked among the first ten included: prevention and management of diarrhoea; management of upper and lower feeding intolerance, including indications for post-pyloric feeding and opioid antagonists; acute gastrointestinal injury grading as a bedside tool; the role of intra-abdominal hypertension in the development and monitoring of GI dysfunction and in the development of non-occlusive mesenteric ischaemia; and the effect of proton pump inhibitors on the microbiome in critical illness.
Current evidence on GI dysfunction is scarce, partially due to the lack of precise definitions. The use of core sets of monitoring and outcomes are required to improve the consistency of future studies. We propose several areas for consensus process and outline future study projects.
Keywords
Critical Care/methods, Critical Care/trends, Critical Illness/epidemiology, Critical Illness/therapy, Diagnostic Imaging/methods, Europe/epidemiology, Gastrointestinal Diseases/diagnosis, Gastrointestinal Diseases/physiopathology, Humans, Nutritional Status/drug effects, Nutritional Status/physiology, Critically ill, Gastrointestinal dysfunction, Gastrointestinal failure, Gastrointestinal function, Intensive care, Monitoring
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2020 20:14
Last modification date
08/08/2024 6:32
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