Coronary vasomotor control in obesity and morbid obesity: contrasting flow responses with endocannabinoids, leptin, and inflammation.

Détails

ID Serval
serval:BIB_3C0CAA3D7EA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Coronary vasomotor control in obesity and morbid obesity: contrasting flow responses with endocannabinoids, leptin, and inflammation.
Périodique
Jacc. Cardiovascular Imaging
Auteur(s)
Quercioli A., Pataky Z., Montecucco F., Carballo S., Thomas A., Staub C., Di Marzo V., Vincenti G., Ambrosio G., Ratib O., Golay A., Mach F., Harsch E., Schindler T.H.
ISSN
1876-7591 (Electronic)
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
5
Numéro
8
Pages
805-815
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
OBJECTIVES: This study sought to investigate abnormalities in coronary circulatory function in 2 different disease entities of obese (OB) and morbidly obese (MOB) individuals and to evaluate whether these would differ in severity with different profiles of endocannabinoids, leptin, and C-reactive protein (CRP) plasma levels.
BACKGROUND: There is increasing evidence that altered plasma levels of endocannabinoids, leptin, and CRP may affect coronary circulatory function in OB and MOB.
METHODS: Myocardial blood flow (MBF) responses to cold pressor test from rest and during pharmacologically induced hyperemia were measured with N-13 ammonia positron emission tomography/computed tomography. Study participants (n = 111) were divided into 4 groups based on their body mass index (BMI) (kg/m(2)): 1) control group (BMI: 20 to 24.9, n = 30); 2) overweight group (BMI: 25 to 29.9, n = 31), 3) OB group (BMI: 30 to 39.9, n = 25); and 4) MOB group (BMI ≥40, n = 25).
RESULTS: The cold pressor test-induced change in endothelium-related MBF response (ΔMBF) progressively declined in overweight and OB groups when compared with the control group [median: 0.19 (interquartile range [IQR] 0.08, 0.27) and 0.11 (0.03, 0.17) vs. 0.27 (0.23, 0.38) ml/g/min; p ≤ 0.01, respectively], whereas it did not differ significantly between OB and MOB groups [median: 0.11 (IQR: 0.03, 0.17) and 0.09 (-0.01, 0.19) ml/g/min; p = 0.93]. Compared with control subjects, hyperemic MBF subjects comparably declined in the overweight, OB, and MOB groups [median: 2.40 (IQR 1.92, 2.63) vs. 1.94 (1.65, 2.30), 2.05 (1.67, 2.38), and 2.14 (1.78, 2.76) ml/g/min; p ≤ 0.05, respectively]. In OB individuals, ΔMBF was inversely correlated with increase in endocannabinoid anandamide (r = -0.45, p = 0.044), but not with leptin (r = -0.02, p = 0.946) or with CRP (r = -0.33, p = 0.168). Conversely, there was a significant and positive correlation among ΔMBF and elevated leptin (r = 0.43, p = 0.031) and CRP (r = 0.55, p = 0.006), respectively, in MOB individuals that was not observed for endocannabinoid anandamide (r = 0.07, p = 0.740).
CONCLUSIONS: Contrasting associations of altered coronary endothelial function with increases in endocannabinoid anandamide, leptin, and CRP plasma levels identify and characterize OB and MOB as different disease entities affecting coronary circulatory function.
Mots-clé
Adipokines/blood, Adult, Body Mass Index, C-Reactive Protein/analysis, Cardiovascular System/physiopathology, Coronary Circulation/drug effects, Coronary Circulation/physiology, Endocannabinoids/blood, Endothelium, Vascular/physiology, Female, Humans, Leptin/blood, Middle Aged, Multimodal Imaging, Muscle, Smooth, Vascular/physiology, Obesity/blood, Obesity/physiopathology, Obesity, Morbid/blood, Obesity, Morbid/physiopathology, Positron-Emission Tomography, Regional Blood Flow/drug effects, Tomography, X-Ray Computed, Vasodilation/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/02/2015 12:55
Dernière modification de la notice
08/05/2019 17:21
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