Assessment of coronary vasoreactivity by multidetector computed tomography: feasibility study with rubidium-82 cardiac positron emission tomography.

Détails

ID Serval
serval:BIB_3B936E95E0BA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessment of coronary vasoreactivity by multidetector computed tomography: feasibility study with rubidium-82 cardiac positron emission tomography.
Périodique
Circulation journal : official journal of the Japanese Circulation Society
Auteur(s)
Dunet V., Qanadli S.D., Allenbach G., Dabiri A., Mazzolai L., Waeber B., Feihl F., Prior J.O.
ISSN
1347-4820 (Electronic)
ISSN-L
1346-9843
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
76
Numéro
1
Pages
160-167
Langue
anglais
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Positron emission tomography (PET) during the cold pressor test (CPT) has been used to assess endothelium-dependent coronary vasoreactivity, a surrogate marker of cardiovascular events. However, its use remains limited by cardiac PET availability. As multidetector computed tomography (MDCT) is more widely available, we aimed to develop a measurement of endothelium-dependent coronary vasoreactivity with MDCT and similar radiation burden as with PET.
A study group of 18 participants without known cardiovascular risk factor (9F/9M; age 60±6 years) underwent cardiac PET with (82)Rb and unenhanced ECG-gated MDCT within 4h, each time at rest and during CPT. The relation between absolute myocardial blood flow (MBF) response to CPT by PET (ml·min(-1)·g(1)) and relative changes in MDCT-measured coronary artery surface were assessed using linear regression analysis and Spearman's correlation. MDCT and PET/CT were analyzed in all participants. Hemodynamic conditions during CPT at MDCT and PET were similar (P>0.3). Relative changes in coronary artery surface because of CPT (2.0-21.2%) correlated to changes in MBF (-0.10-0.52ml·min(-1)·g(1)) (ρ=0.68, P=0.02). Effective dose was 1.3±0.2mSv for MDCT and 3.1mSv for PET/CT.
Assessment of endothelium-dependent coronary vasoreactivity using MDCT CPT appears feasible. Because of its wider availability, shorter examination time and similar radiation burden, MDCT could be attractive in clinical research for coronary status assessment.

Mots-clé
Aged, Coronary Vessels/diagnostic imaging, Coronary Vessels/physiology, Endothelium, Vascular/diagnostic imaging, Endothelium, Vascular/physiology, Feasibility Studies, Female, Hemodynamics/physiology, Humans, Linear Models, Male, Middle Aged, Multidetector Computed Tomography, Muscle, Smooth, Vascular/diagnostic imaging, Muscle, Smooth, Vascular/physiology, Positron-Emission Tomography, Regional Blood Flow/physiology, Rubidium Radioisotopes, Ultrasonography, Vasomotor System/diagnostic imaging, Vasomotor System/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/12/2011 19:42
Dernière modification de la notice
20/08/2019 14:31
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