A review of malaria vaccine clinical projects based on the WHO rainbow table.

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Ressource 1Download: BIB_3B6F57ECD9C5.P001.pdf (417.83 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_3B6F57ECD9C5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A review of malaria vaccine clinical projects based on the WHO rainbow table.
Journal
Malaria Journal
Author(s)
Schwartz L., Brown G.V., Genton B., Moorthy V.S.
ISSN
1475-2875 (Electronic)
ISSN-L
1475-2875
Publication state
Published
Issued date
2012
Volume
11
Number
11
Pages
1-22
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: epublish
Abstract
Development and Phase 3 testing of the most advanced malaria vaccine, RTS,S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of several research malaria vaccines have also confirmed that it is possible to impact the host-parasite relationship through vaccine-induced immune responses to multiple antigenic targets using different platforms. Other approaches have been appropriately tested but turned out to be disappointing after clinical evaluation. As the malaria community considers the potential role of a first-generation malaria vaccine in malaria control efforts, it is an apposite time to carefully document terminated and ongoing malaria vaccine research projects so that lessons learned can be applied to increase the chances of success for second-generation malaria vaccines over the next 10 years. The most comprehensive resource of malaria vaccine projects is a spreadsheet compiled by WHO thanks to the input from funding agencies, sponsors and investigators worldwide. This spreadsheet, available from WHO's website, is known as "the rainbow table". By summarizing the published and some unpublished information available for each project on the rainbow table, the most comprehensive review of malaria vaccine projects to be published in the last several years is provided below.
Keywords
Biomedical Research/trends, Clinical Trials as Topic, Databases, Factual, Drug Discovery/trends, Humans, Internet, Malaria/epidemiology, Malaria/prevention & control, Malaria Vaccines/administration & dosage, Malaria Vaccines/immunology, World Health Organization
Pubmed
Web of science
Open Access
Yes
Create date
12/02/2013 15:12
Last modification date
20/08/2019 13:31
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