Volume loss of the medial temporal lobe structures in subjective memory impairment.
Details
Serval ID
serval:BIB_3B4AC3A1CF80
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Volume loss of the medial temporal lobe structures in subjective memory impairment.
Journal
Dementia and Geriatric Cognitive Disorders
ISSN
1421-9824 (Electronic)
ISSN-L
1420-8008
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
29
Number
1
Pages
75-81
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
BACKGROUND/AIMS: Subjective memory impairment (SMI) has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI.
METHODS: Regional volumetric measures were manually traced on 3-Tesla MRI scans.
RESULTS: Total brain volume did not differ between the groups. Individuals with SMI had reduced volumes of the hippocampus bilaterally (right p = 0.001; left p < 0.001), the bilateral EC (right p = 0.031, left p = 0.006) and the right amygdala (p = 0.01) compared to the control group.
CONCLUSION: Volume reduction of bilateral hippocampus, bilateral EC and right amygdala supports the concept of SMI as a very early manifestation of AD prior to MCI. SMI may indicate awareness of a degenerative process that can still be functionally compensated.
METHODS: Regional volumetric measures were manually traced on 3-Tesla MRI scans.
RESULTS: Total brain volume did not differ between the groups. Individuals with SMI had reduced volumes of the hippocampus bilaterally (right p = 0.001; left p < 0.001), the bilateral EC (right p = 0.031, left p = 0.006) and the right amygdala (p = 0.01) compared to the control group.
CONCLUSION: Volume reduction of bilateral hippocampus, bilateral EC and right amygdala supports the concept of SMI as a very early manifestation of AD prior to MCI. SMI may indicate awareness of a degenerative process that can still be functionally compensated.
Keywords
Aged, Amygdala/pathology, Apolipoproteins E/genetics, Brain/pathology, Education, Entorhinal Cortex/pathology, Female, Functional Laterality/physiology, Hippocampus/pathology, Humans, Magnetic Resonance Imaging, Male, Memory Disorders/pathology, Memory Disorders/psychology, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Temporal Lobe/pathology
Pubmed
Create date
29/10/2012 12:39
Last modification date
20/08/2019 14:31
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