Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

Détails

Ressource 1Télécharger: 24136355 (1).pdf (752.80 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_3B38B04B8D47
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.
Périodique
Science
Auteur(s)
Kilpinen H., Waszak S.M., Gschwind A.R., Raghav S.K., Witwicki R.M., Orioli A., Migliavacca E., Wiederkehr M., Gutierrez-Arcelus M., Panousis N.I., Yurovsky A., Lappalainen T., Romano-Palumbo L., Planchon A., Bielser D., Bryois J., Padioleau I., Udin G., Thurnheer S., Hacker D., Core L.J., Lis J.T., Hernandez N., Reymond A., Deplancke B., Dermitzakis E.T.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2013
Volume
342
Numéro
6159
Pages
744-747
Langue
anglais
Résumé
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event.
Pubmed
Web of science
Création de la notice
28/11/2013 10:43
Dernière modification de la notice
03/03/2018 16:17
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