Neuroactive metabolites modulated by the gut microbiota in honey bees.
Details
Download: 37718573.pdf (957.02 [Ko])
State: Public
Version: Final published version
License: CC BY-NC 4.0
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_3ADF7D01186D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neuroactive metabolites modulated by the gut microbiota in honey bees.
Journal
Molecular microbiology
ISSN
1365-2958 (Electronic)
ISSN-L
0950-382X
Publication state
Published
Issued date
09/2024
Peer-reviewed
Oui
Volume
122
Number
3
Pages
284-293
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Honey bees have emerged as a new model to study the gut-brain axis, as they exhibit complex social behaviors and cognitive abilities, while experiments with gnotobiotic bees have revealed that their gut microbiota alters both brain and behavioral phenotypes. Furthermore, while honey bee brain functions supporting a broad range of behaviors have been intensively studied for over 50 years, the gut microbiota of bees has been experimentally characterized only recently. Here, we combined six published datasets from metabolomic analyses to provide an overview of the neuroactive metabolites whose abundance in the gut, hemolymph and brain varies in presence of the gut microbiota. Such metabolites may either be produced by gut bacteria, released from the pollen grains during their decomposition by bacteria, or produced by other organs in response to different bacterial products. We describe the current state of knowledge regarding the impact of such metabolites on brain function and behavior and provide further hypotheses to explore in this emerging field of research.
Keywords
Bees/microbiology, Animals, Gastrointestinal Microbiome/physiology, Brain/metabolism, Metabolomics, Bacteria/metabolism, Bacteria/genetics, Behavior, Animal, Brain-Gut Axis/physiology, Hemolymph/metabolism, Hemolymph/microbiology, Metabolome, Apis, bacteria, behavior, brain, nutrition, symbiosis
Pubmed
Web of science
Open Access
Yes
Create date
25/09/2023 16:49
Last modification date
29/10/2024 7:21