New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

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State: Public
Version: author
Serval ID
serval:BIB_3AD8785589CA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Journal
Nature Communications
Author(s)
Lu Y., Day F.R., Gustafsson S., Buchkovich M.L., Na J., Bataille V., Cousminer D.L., Dastani Z., Drong A.W., Esko T., Evans D.M., Falchi M., Feitosa M.F., Ferreira T., Hedman Å.K., Haring R., Hysi P.G., Iles M.M., Justice A.E., Kanoni S., Lagou V., Li R., Li X., Locke A., Lu C., Mägi R., Perry J.R., Pers T.H., Qi Q., Sanna M., Schmidt E.M., Scott W.R., Shungin D., Teumer A., Vinkhuyzen A.A., Walker R.W., Westra H.J., Zhang M., Zhang W., Zhao J.H., Zhu Z., Afzal U., Ahluwalia T.S., Bakker S.J., Bellis C., Bonnefond A., Borodulin K., Buchman A.S., Cederholm T., Choh A.C., Choi H.J., Curran J.E., de Groot L.C., De Jager P.L., Dhonukshe-Rutten R.A., Enneman A.W., Eury E., Evans D.S., Forsen T., Friedrich N., Fumeron F., Garcia M.E., Gärtner S., Han B.G., Havulinna A.S., Hayward C., Hernandez D., Hillege H., Ittermann T., Kent J.W., Kolcic I., Laatikainen T., Lahti J., Mateo Leach I., Lee C.G., Lee J.Y., Liu T., Liu Y., Lobbens S., Loh M., Lyytikäinen L.P., Medina-Gomez C., Michaëlsson K., Nalls M.A., Nielson C.M., Oozageer L., Pascoe L., Paternoster L., Polašek O., Ripatti S., Sarzynski M.A., Shin C.S., Narančić N.S., Spira D., Srikanth P., Steinhagen-Thiessen E., Sung Y.J., Swart K.M., Taittonen L., Tanaka T., Tikkanen E., van der Velde N., van Schoor N.M., Verweij N., Wright A.F., Yu L., Zmuda J.M., Eklund N., Forrester T., Grarup N., Jackson A.U., Kristiansson K., Kuulasmaa T., Kuusisto J., Lichtner P., Luan J., Mahajan A., Männistö S., Palmer C.D., Ried J.S., Scott R.A., Stancáková A., Wagner P.J., Demirkan A., Döring A., Gudnason V., Kiel D.P., Kühnel B., Mangino M., Mcknight B., Menni C., O'Connell J.R., Oostra B.A., Shuldiner A.R., Song K., Vandenput L., van Duijn C.M., Vollenweider P., White C.C., Boehnke M., Boettcher Y., Cooper R.S., Forouhi N.G., Gieger C., Grallert H., Hingorani A., Jørgensen T., Jousilahti P., Kivimaki M., Kumari M., Laakso M., Langenberg C., Linneberg A., Luke A., Mckenzie C.A., Palotie A., Pedersen O., Peters A., Strauch K., Tayo B.O., Wareham N.J., Bennett D.A., Bertram L., Blangero J., Blüher M., Bouchard C., Campbell H., Cho N.H., Cummings S.R., Czerwinski S.A., Demuth I., Eckardt R., Eriksson J.G., Ferrucci L., Franco O.H., Froguel P., Gansevoort R.T., Hansen T., Harris T.B., Hastie N., Heliövaara M., Hofman A., Jordan J.M., Jula A., Kähönen M., Kajantie E., Knekt P.B., Koskinen S., Kovacs P., Lehtimäki T., Lind L., Liu Y., Orwoll E.S., Osmond C., Perola M., Pérusse L., Raitakari O.T., Rankinen T., Rao D.C., Rice T.K., Rivadeneira F., Rudan I., Salomaa V., Sørensen T.I., Stumvoll M., Tönjes A., Towne B., Tranah G.J., Tremblay A., Uitterlinden A.G., van der Harst P., Vartiainen E., Viikari J.S., Vitart V., Vohl M.C., Völzke H., Walker M., Wallaschofski H., Wild S., Wilson J.F., Yengo L., Bishop D.T., Borecki I.B., Chambers J.C., Cupples L.A., Dehghan A., Deloukas P., Fatemifar G., Fox C., Furey T.S., Franke L., Han J., Hunter D.J., Karjalainen J., Karpe F., Kaplan R.C., Kooner J.S., McCarthy M.I., Murabito J.M., Morris A.P., Bishop J.A., North K.E., Ohlsson C., Ong K.K., Prokopenko I., Richards J.B., Schadt E.E., Spector T.D., Widén E., Willer C.J., Yang J., Ingelsson E., Mohlke K.L., Hirschhorn J.N., Pospisilik J.A., Zillikens M.C., Lindgren C., Kilpeläinen T.O., Loos R.J.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
7
Pages
10495
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: epublish
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Keywords
Adiposity/genetics, Animals, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Gene Expression Regulation/physiology, Gene Knockdown Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Diseases/genetics, Humans, Quantitative Trait Loci/genetics
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2016 17:24
Last modification date
20/08/2019 13:30
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