Yeast-to-hypha transition of Schizosaccharomyces japonicus in response to environmental stimuli.

Détails

ID Serval
serval:BIB_3A8D90BECDB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Yeast-to-hypha transition of Schizosaccharomyces japonicus in response to environmental stimuli.
Périodique
Molecular biology of the cell
Auteur(s)
Kinnaer C., Dudin O., Martin S.G.
ISSN
1939-4586 (Electronic)
ISSN-L
1059-1524
Statut éditorial
Publié
Date de publication
01/04/2019
Peer-reviewed
Oui
Volume
30
Numéro
8
Pages
975-991
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Many fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus. Here, we first identify fruit extracts as natural, stress-free, starvation-independent inducers of filamentation, which we use to describe the properties of the dimorphic switch. During the yeast-to-hypha transition, the cell evolves from a bipolar to a unipolar system with 10-fold accelerated polarized growth but constant width, vacuoles segregated to the nongrowing half of the cell, and hyper-lengthening of the cell. We demonstrate unusual features of S. japonicus hyphae: these cells lack a Spitzenkörper, a vesicle distribution center at the hyphal tip, but display more rapid cytoskeleton-based transport than the yeast form, with actin cables being essential for the transition. S. japonicus hyphae also remain mononuclear and undergo complete cell divisions, which are highly asymmetric: one daughter cell inherits the vacuole, the other the growing tip. We show that these elongated cells scale their nuclear size, spindle length, and elongation rates, but display altered division size controls. This establishes S. japonicus as a unique system that switches between symmetric and asymmetric modes of growth and division.
Mots-clé
Cell Cycle/genetics, Cell Division/genetics, Cytoskeleton/physiology, Fungal Proteins/genetics, Fungi/cytology, Hyphae/cytology, Microtubules/physiology, Schizosaccharomyces/cytology, Schizosaccharomyces/metabolism, Vacuoles/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/03/2019 19:15
Dernière modification de la notice
20/08/2019 14:30
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