Copper metabolism and requirements in total parenteral nutrition

Details

Serval ID
serval:BIB_3A498811E272
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Copper metabolism and requirements in total parenteral nutrition
Journal
Gastroenterology
Author(s)
Shike  M., Roulet  M., Kurian  R., Whitwell  J., Stewart  S., Jeejeebhoy  K. N.
ISSN
0016-5085 (Print)
Publication state
Published
Issued date
08/1981
Volume
81
Number
2
Pages
290-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Copper metabolism and requirements in patients receiving total parenteral nutrition were studied in 28 patients with gastrointestinal diseases. During each of the 3 wk of the study period, each of 24 patients received in their total parenteral nutrition solutions, a daily dose of copper amounting to 0.25 mg, 1.05 mg, or 1.85 mg, in a random order. The other 4 patients received a fixed daily dose of 1 mg throughout the 3 wk. Increased losses of copper through the gastrointestinal tract occurred in patients with diarrhea or high-output stomas or fistulas. Patients with abnormalities of liver excretory functions had decreases in gastrointestinal copper losses. Urinary copper excretion was twice that of normal subjects. Copper infused in excess of the requirements was retained and not excreted. Plasma copper did not reflect the copper balance and cannot be used as a guide for copper supplementation. Copper requirements were found to be 0.3 mg/day in patients with normal amounts of gastrointestinal excretion. In the presence of diarrhea or increased fluid loss through gastrointestinal stomas or fistulas, the copper requirements for total parenteral nutrition are 0.4--0.5 mg/day.
Keywords
Adolescent Adult Ceruloplasmin/metabolism Copper/blood/*metabolism/urine Digestive System/metabolism Female Gastrointestinal Diseases/metabolism/therapy Hair/metabolism Humans Iron/blood Male *Nutrition Physiology *Nutritional Requirements *Parenteral Nutrition *Parenteral Nutrition, Total
Pubmed
Web of science
Create date
24/01/2008 20:33
Last modification date
20/08/2019 13:29
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