Factors other than glomerular filtration rate affect serum cystatin C levels

Détails

Ressource 1Télécharger: Stevens non-GFR SCysC determinants Kidney int 2009.pdf (174.92 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_3A0A01A3F2B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Factors other than glomerular filtration rate affect serum cystatin C levels
Périodique
Kidney International
Auteur(s)
Stevens L. A., Schmid C. H., Greene T., Li L., Beck G. J., Joffe M. M., Froissart M., Kusek J. W., Zhang Y. L., Coresh J., Levey A. S.
ISSN
0085-2538
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
75
Numéro
6
Pages
652-60
Langue
anglais
Notes
Stevens, Lesley A
Schmid, Christopher H
Greene, Tom
Li, Liang
Beck, Gerald J
Joffe, Marshall M
Froissart, Marc
Kusek, John W
Zhang, Yaping Lucy
Coresh, Josef
Levey, Andrew S
eng
K23 DK081017/DK/NIDDK NIH HHS/
U01 DK 053869/DK/NIDDK NIH HHS/
U01 DK 067651/DK/NIDDK NIH HHS/
U01 DK 35073/DK/NIDDK NIH HHS/
U01 DK035073/DK/NIDDK NIH HHS/
U01 DK053869/DK/NIDDK NIH HHS/
U01 DK067651/DK/NIDDK NIH HHS/
Research Support, N.I.H., Extramural
2009/01/03 09:00
Kidney Int. 2009 Mar;75(6):652-60. doi: 10.1038/ki.2008.638. Epub 2008 Dec 31.
Résumé
Cystatin C is an endogenous glomerular filtration marker hence its serum level is affected by the glomerular filtration rate (GFR). To study what other factors might affect it blood level we performed a cross-sectional analysis of 3418 patients which included a pooled dataset of clinical trial participants and a clinical population with chronic kidney disease. The serum cystatin C and creatinine levels were related to clinical and biochemical parameters and errors-in-variables models were used to account for errors in GFR measurements. The GFR was measured as the urinary clearance of 125I-iothalamate and 51Cr-EDTA. Cystatin C was determined at a single laboratory while creatinine was standardized to reference methods and these were 2.1+/-1.1 mg/dL and 1.8+/-0.8 mg/L, respectively. After adjustment for GFR, cystatin C was 4.3% lower for every 20 years of age, 9.2% lower for female gender but only 1.9% lower in blacks. Diabetes was associated with 8.5% higher levels of cystatin C and 3.9% lower levels of creatinine. Higher C-reactive protein and white blood cell count and lower serum albumin were associated with higher levels of cystatin C and lower levels of creatinine. Adjustment for age, gender and race had a greater effect on the association of factors with creatinine than cystatin C. Hence, we found that cystatin C is affected by factors other than GFR which should be considered when the GFR is estimated using serum levels of cystatin C.
Mots-clé
Age Factors, Continental Population Groups, Creatinine/*blood, Cross-Sectional Studies, Cystatin C/*blood, Female, *Glomerular Filtration Rate, Humans, Kidney Function Tests/methods, Male, Predictive Value of Tests, Sex Factors
Pubmed
Open Access
Oui
Création de la notice
03/03/2016 17:49
Dernière modification de la notice
20/08/2019 14:29
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