How confident can we be that orthologs are similar, but paralogs differ?

Détails

Ressource 1Télécharger: BIB_39F8106EE698.P001.pdf (395.64 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_39F8106EE698
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
How confident can we be that orthologs are similar, but paralogs differ?
Périodique
Trends in Genetics
Auteur(s)
Studer R.A., Robinson-Rechavi M.
ISSN
0168-9525
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
25
Numéro
5
Pages
210-216
Langue
anglais
Résumé
Homologous genes are classified into orthologs and paralogs, depending on whether they arose by speciation or duplication. It is widely assumed that orthologs share similar functions, whereas paralogs are expected to diverge more from each other. But does this assumption hold up on further examination? We present evidence that orthologs and paralogs are not so different in either their evolutionary rates or their mechanisms of divergence. We emphasize the importance of appropriately designed studies to test models of gene evolution between orthologs and between paralogs. Thus, functional change between orthologs might be as common as between paralogs, and future studies should be designed to test the impact of duplication against this alternative model.
Web of science
Open Access
Oui
Création de la notice
16/03/2009 21:57
Dernière modification de la notice
20/08/2019 14:29
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