Corneal penetration of diclofenac from a fixed combination of diclofenac-gentamicin eyedrops.

Détails

ID Serval
serval:BIB_39AA1C2DD099
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Corneal penetration of diclofenac from a fixed combination of diclofenac-gentamicin eyedrops.
Périodique
Journal of Cataract and Refractive Surgery
Auteur(s)
Killer H.E., Borruat F.X., Blumer B.K., Herbort C.P., Jauch A.
ISSN
0886-3350 (Print)
ISSN-L
0886-3350
Statut éditorial
Publié
Date de publication
10/1998
Peer-reviewed
Oui
Volume
24
Numéro
10
Pages
1365-1370
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
PURPOSE: To establish the corneal penetration of diclofenac in the presence of gentamicin in patients having cataract surgery.
SETTING: Kantonsspital Augenklinik, Aarau, and Hôpital Jules Gonin, Lausanne, Switzerland.
METHODS: Eligible patients having cataract surgery (39 women, 30 men) were treated with 4 drops of diclofenac 0.1%-gentamicin 0.3% (Voltamicin) instilled at 20 minute intervals. Paracentesis was performed 15, 30, or 60 minutes after the last instillation, and a sample of aqueous humor was collected for analysis of diclofenac by high-performance liquid chromatography. Blood samples of some patients were obtained before surgery for analysis.
RESULTS: Mean diclofenac levels (+/- SD) in the aqueous humor 15, 30, and 60 minutes after the last instillation were 72 +/- 84, 108 +/- 87, and 201 +/- 116 ng/mL (= 682 nMol/L), respectively. Diclofenac remained below the limit of detection (5 ng/mL) in all samples of blood serum. In general, local tolerance was good; no side effects were reported. Comparison of the data with published results of topically instilled diclofenac 0.1% suggests that the concentration of diclofenac in the aqueous humor achieved with 4 instillations of the combination product is similar to that achieved with 8 instillations of diclofenac 0.1% (Voltaren Ophtha) alone.
CONCLUSIONS: Drug levels of diclofenac in the aqueous humor well above IC-50 for cyclo-oxygenase were achieved with the regimen applied. No inhibitory effect by the gentamicin or vehicle was observed. Comparison of these data with published results of Voltaren Ophtha implies a 2-fold better penetration of diclofenac with the diclofenac-gentamicin combination.
Mots-clé
Aged, Anti-Bacterial Agents/administration & dosage, Anti-Bacterial Agents/pharmacokinetics, Anti-Inflammatory Agents, Non-Steroidal/administration & dosage, Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics, Aqueous Humor/metabolism, Cataract Extraction, Chromatography, High Pressure Liquid, Cornea/metabolism, Diclofenac/administration & dosage, Diclofenac/pharmacokinetics, Drug Therapy, Combination, Female, Gentamicins/administration & dosage, Gentamicins/pharmacokinetics, Humans, Male, Ophthalmic Solutions
Pubmed
Web of science
Création de la notice
28/01/2008 12:38
Dernière modification de la notice
20/08/2019 13:29
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