Functional integration of "undead" neurons in the olfactory system.

Détails

ID Serval
serval:BIB_39A62FD7ACE6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Functional integration of "undead" neurons in the olfactory system.
Périodique
Science advances
Auteur(s)
Prieto-Godino L.L. (co-premier), Silbering A.F. (co-premier), Khallaf M.A., Cruchet S., Bojkowska K., Pradervand S., Hansson B.S., Knaden M., Benton R.
ISSN
2375-2548 (Electronic)
ISSN-L
2375-2548
Statut éditorial
Publié
Date de publication
03/2020
Peer-reviewed
Oui
Volume
6
Numéro
11
Pages
eaaz7238
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Programmed cell death (PCD) is widespread during neurodevelopment, eliminating the surpluses of neuronal production. Using the Drosophila olfactory system, we examined the potential of cells fated to die to contribute to circuit evolution. Inhibition of PCD is sufficient to generate new cells that express neural markers and exhibit odor-evoked activity. These "undead" neurons express a subset of olfactory receptors that is enriched for relatively recent receptor duplicates and includes some normally found in different chemosensory organs and life stages. Moreover, undead neuron axons integrate into the olfactory circuitry in the brain, forming novel receptor/glomerular couplings. Comparison of homologous olfactory lineages across drosophilids reveals natural examples of fate change from death to a functional neuron. Last, we provide evidence that PCD contributes to evolutionary differences in carbon dioxide-sensing circuit formation in Drosophila and mosquitoes. These results reveal the remarkable potential of alterations in PCD patterning to evolve new neural pathways.
Pubmed
Open Access
Oui
Création de la notice
02/05/2019 18:00
Dernière modification de la notice
02/04/2020 6:19
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