Update on hepatitis E virology: Implications for clinical practice.

Détails

ID Serval
serval:BIB_3997EA19F750
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Update on hepatitis E virology: Implications for clinical practice.
Périodique
Journal of hepatology
Auteur(s)
Debing Y., Moradpour D., Neyts J., Gouttenoire J.
ISSN
1600-0641 (Electronic)
ISSN-L
0168-8278
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
65
Numéro
1
Pages
200-212
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Hepatitis E virus (HEV) is a positive-strand RNA virus transmitted by the fecal-oral route. The 7.2kb genome encodes three open reading frames (ORF) which are translated into (i) the ORF1 polyprotein, representing the viral replicase, (ii) the ORF2 protein, corresponding to the viral capsid, and (iii) the ORF3 protein, a small protein involved in particle secretion. Although HEV is a non-enveloped virus in bile and feces, it circulates in the bloodstream wrapped in cellular membranes. HEV genotypes 1 and 2 infect only humans and cause mainly waterborne outbreaks. HEV genotypes 3 and 4 are widely represented in the animal kingdom and are transmitted as a zoonosis mainly via contaminated meat. HEV infection is usually self-limited but may persist and cause chronic hepatitis in immunocompromised patients. Reduction of immunosuppressive treatment or antiviral therapy with ribavirin have proven effective in most patients with chronic hepatitis E but therapy failures have been reported. Alternative treatment options are needed, therefore. Infection with HEV may also cause a number of extrahepatic manifestations, especially neurologic complications. Progress in the understanding of the biology of HEV should contribute to improved control and treatment of HEV infection.

Mots-clé
Animals, Feces, Hepatitis E, Hepatitis E virus, Humans, Open Reading Frames, Ribavirin, Antivirals, Chronic hepatitis, Positive-strand RNA virus, Tissue tropism, Zoonotic infection
Pubmed
Web of science
Création de la notice
17/03/2016 19:17
Dernière modification de la notice
20/08/2019 14:29
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