Update on hepatitis E virology: Implications for clinical practice.

Details

Serval ID
serval:BIB_3997EA19F750
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Update on hepatitis E virology: Implications for clinical practice.
Journal
Journal of hepatology
Author(s)
Debing Y., Moradpour D., Neyts J., Gouttenoire J.
ISSN
1600-0641 (Electronic)
ISSN-L
0168-8278
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
65
Number
1
Pages
200-212
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Hepatitis E virus (HEV) is a positive-strand RNA virus transmitted by the fecal-oral route. The 7.2kb genome encodes three open reading frames (ORF) which are translated into (i) the ORF1 polyprotein, representing the viral replicase, (ii) the ORF2 protein, corresponding to the viral capsid, and (iii) the ORF3 protein, a small protein involved in particle secretion. Although HEV is a non-enveloped virus in bile and feces, it circulates in the bloodstream wrapped in cellular membranes. HEV genotypes 1 and 2 infect only humans and cause mainly waterborne outbreaks. HEV genotypes 3 and 4 are widely represented in the animal kingdom and are transmitted as a zoonosis mainly via contaminated meat. HEV infection is usually self-limited but may persist and cause chronic hepatitis in immunocompromised patients. Reduction of immunosuppressive treatment or antiviral therapy with ribavirin have proven effective in most patients with chronic hepatitis E but therapy failures have been reported. Alternative treatment options are needed, therefore. Infection with HEV may also cause a number of extrahepatic manifestations, especially neurologic complications. Progress in the understanding of the biology of HEV should contribute to improved control and treatment of HEV infection.

Keywords
Animals, Feces, Hepatitis E, Hepatitis E virus, Humans, Open Reading Frames, Ribavirin, Antivirals, Chronic hepatitis, Positive-strand RNA virus, Tissue tropism, Zoonotic infection
Pubmed
Web of science
Create date
17/03/2016 18:17
Last modification date
20/08/2019 13:29
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