Sexual dimorphism in cancer.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_393065D9F168
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Sexual dimorphism in cancer.
Périodique
Nature Reviews. Cancer
Auteur(s)
Clocchiatti A., Cora E., Zhang Y., Dotto G.P.
ISSN
1474-1768 (Electronic)
ISSN-L
1474-175X
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
16
Numéro
5
Pages
330-339
Langue
anglais
Résumé
The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival. Occupational and/or behavioural factors are well-known underlying determinants. However, cellular and molecular differences between the two sexes are also likely to be important. In this Opinion article, we focus on the complex interplay that sex hormones and sex chromosomes can have in intrinsic control of cancer-initiating cell populations, the tumour microenvironment and systemic determinants of cancer development, such as the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/05/2016 17:03
Dernière modification de la notice
20/08/2019 13:28
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