Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients

Détails

Ressource 1Télécharger: BIB_391E280A3DF2.P001.pdf (881.32 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_391E280A3DF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients
Périodique
Plos One
Auteur(s)
Otto B., Koenig A.M., Tolstonog G.V., Jeschke A., Klaetschke K., Vashist Y.K., Wicklein D., Wagener C., Izbicki J.R., Streichert T.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
7
Pages
e102552
Langue
anglais
Notes
Publication types: Research Article ; research-article Identifiant PubMed Central: PMC4105535
Résumé
Lymph node metastasis indicates poor prognosis in esophageal cancer. To understand the underlying mechanisms, most studies so far focused on investigating the tumors themselves and/or invaded lymph nodes. However they neglected the potential events within the metastatic niche, which precede invasion. Here we report the first description of these regulations in patients on transcription level. We determined transcriptomic profiles of still metastasis-free regional lymph nodes for two patient groups: patients classified as pN1 (n = 9, metastatic nodes exist) or pN0 (n = 5, no metastatic nodes exist). All investigated lymph nodes, also those from pN1 patients, were still metastasis-free. The results show that regional lymph nodes of pN1 patients differ decisively from those of pN0 patients--even before metastasis has taken place. In the pN0 group distinct immune response patterns were observed. In contrast, lymph nodes of the pN1 group exhibited a clear profile of reduced immune response and reduced proliferation, but increased apoptosis, enhanced hypoplasia and morphological conversion processes. DKK1 was the most significant gene associated with the molecular mechanisms taking place in lymph nodes of patients suffering from metastasis (pN1). We assume that the two molecular profiles observed constitute different stages of a progressive disease. Finally we suggest that DKK1 might play an important role within the mechanisms leading to lymph node metastasis.
Mots-clé
Esophageal Neoplasms/genetics, Esophageal Neoplasms/pathology, Esophagus/metabolism, Esophagus/pathology, Intercellular Signaling Peptides and Proteins/genetics, Lymph Nodes/metabolism, Lymph Nodes/pathology, Lymphatic Metastasis/diagnosis, Lymphatic Metastasis/genetics
Pubmed
Web of science
Création de la notice
11/07/2016 11:04
Dernière modification de la notice
03/03/2018 16:12
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