Article: article from journal or magazin.
Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus.
Infection and Immunity
Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
Adhesins, Bacterial/physiology, Animals, Endocarditis, Bacterial/etiology, Fibrinogen/metabolism, Rats, Staphylococcal Infections/etiology
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