Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patients with sepsis or circulatory failure.

Details

Serval ID
serval:BIB_39143D79C3F9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patients with sepsis or circulatory failure.
Journal
Clinical Physiology and Functional Imaging
Author(s)
Martinez A., Chiolero R., Bollman M., Revelly J.P., Berger M., Cayeux C., Tappy L.
ISSN
1475-0961
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
23
Number
5
Pages
286-292
Language
english
Abstract
To evaluate the role of adipose tissue in the metabolic stress response of critically ill patients, the release of glycerol and lactate by subcutaneous adipose tissue was assessed by means of microdialysis in patients with sepsis or circulatory failure and in healthy subjects. Patients with sepsis had lower plasma free fatty acid concentrations and non-significant elevations of plasma glycerol concentrations, but higher adipose-systemic glycerol concentrations gradients than healthy subjects or patients with circulatory failure, indicating a stimulation of subcutaneous adipose lipolysis. They also had a higher lipid oxidation. Lipid metabolism (adipose-systemic glycerol gradients, lipid oxidation) was not altered in patients with circulatory failure. These observations highlight major differences in lipolysis and lipid utilization between patients with sepsis and circulatory failure. Hyperlactataemia was present in both groups of patients, but the adipose-systemic lactate concentration gradient was not increased, indicating that lactate production by adipose tissue was not involved. This speaks against a role of adipose tissue in the development of hyperlactataemia in critically ill patients.
Keywords
Adipose Tissue, Adult, Aged, Blood Glucose, Case-Control Studies, Fatty Acids, Nonesterified, Female, Glucose, Glycerol, Humans, Infection, Insulin, Lactic Acid, Lipid Metabolism, Male, Microdialysis, Middle Aged, Osmolar Concentration, Oxidation-Reduction, Shock
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 13:28
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