Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures.

Détails

Ressource 1Télécharger: 27474071_BIB_390335AE2228.pdf (1977.33 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_390335AE2228
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures.
Périodique
Journal of immunology
Auteur(s)
Nayar S., Campos J., Chung M.M., Navarro-Núñez L., Chachlani M., Steinthal N., Gardner D.H., Rankin P., Cloake T., Caamaño J.H., McGettrick H.M., Watson S.P., Luther S., Buckley C.D., Barone F.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
01/09/2016
Peer-reviewed
Oui
Volume
197
Numéro
5
Pages
1957-1967
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied. Using a viral-induced, resolving model of TLS formation in the salivary glands of adult mice we demonstrate that the expansion of the lymphatic vascular network is tightly regulated. Lymphatic vessel expansion occurs in two distinct phases. The first wave of expansion is dependent on IL-7. The second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (LT)βR signaling. These findings, while highlighting the tight regulation of the lymphatic response to inflammation, suggest that targeting the LTα1β2/LTβR pathway in TLS-associated pathologies might impair a natural proresolving mechanism for lymphocyte exit from the tissues and account for the failure of therapeutic strategies that target these molecules in diseases such as rheumatoid arthritis.

Mots-clé
Animals, Gene Expression Regulation, Inflammation, Interleukin-7/genetics, Interleukin-7/immunology, Interleukin-7/metabolism, Lymphangiogenesis, Lymphatic Vessels/immunology, Lymphatic Vessels/metabolism, Lymphotoxin alpha1, beta2 Heterotrimer/genetics, Lymphotoxin alpha1, beta2 Heterotrimer/immunology, Lymphotoxin alpha1, beta2 Heterotrimer/metabolism, Mice, Salivary Glands/immunology, Signal Transduction/genetics, Signal Transduction/immunology, Tertiary Lymphoid Structures/immunology, Tertiary Lymphoid Structures/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/08/2016 14:23
Dernière modification de la notice
20/08/2019 13:28
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