Inter-generational resemblance of methylation levels at circadian genes and associations with phenology in the barn swallow.

Détails

Ressource 1Télécharger: s41598-019-42798-3.pdf (1327.81 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_388676987F10
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inter-generational resemblance of methylation levels at circadian genes and associations with phenology in the barn swallow.
Périodique
Scientific Reports
Auteur(s)
Saino N., Albetti B., Ambrosini R., Caprioli M., Costanzo A., Mariani J., Parolini M., Romano A., Rubolini D., Formenti G., Gianfranceschi L., Bollati V.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
24/04/2019
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
6505
Langue
anglais
Résumé
Regulation of gene expression can occur via epigenetic effects as mediated by DNA methylation. The potential for epigenetic effects to be transmitted across generations, thus modulating phenotypic variation and affecting ecological and evolutionary processes, is increasingly appreciated. However, the study of variation in epigenomes and inter-generational transmission of epigenetic alterations in wild populations is at its very infancy. We studied sex- and age-related variation in DNA methylation and parent-offspring resemblance in methylation profiles in the barn swallows. We focused on a class of highly conserved 'clock' genes (clock, cry1, per2, per3, timeless) relevant in the timing of activities of major ecological importance. In addition, we considerably expanded previous analyses on the relationship between methylation at clock genes and breeding date, a key fitness trait in barn swallows. We found positive assortative mating for methylation at one clock locus. Methylation varied between the nestling and the adult stage, and according to sex. Individuals with relatively high methylation as nestlings also had high methylation levels when adults. Extensive parent-nestling resemblance in methylation levels was observed. Occurrence of extra-pair fertilizations allowed to disclose evidence hinting at a prevalence of paternal germline or sperm quality effects over common environment effects in generating father-offspring resemblance in methylation. Finally, we found an association between methylation at the clock poly-Q region, but not at other loci, and breeding date. We thus provided evidence for sex-dependent variation and the first account of parent-offspring resemblance in methylation in any wild vertebrate. We also showed that epigenetics may influence phenotypic plasticity of timing of life cycle events, thus having a major impact on fitness.
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/05/2019 12:05
Dernière modification de la notice
20/08/2019 14:27
Données d'usage