Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Ubiquitylation of ion channels.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.
Amino Acid Motifs, Animals, Endoplasmic Reticulum, Humans, Ion Channels, Mutation, Protein Folding, Ubiquitin
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