Ultrasound biomicroscopy evaluation of anterior extension in retinoblastoma: a clinicopathological study.

Détails

ID Serval
serval:BIB_37F50A9D288F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Ultrasound biomicroscopy evaluation of anterior extension in retinoblastoma: a clinicopathological study.
Périodique
The British journal of ophthalmology
Auteur(s)
Moulin A.P., Gaillard M.C., Balmer A., Munier F.L.
ISSN
1468-2079 (Electronic)
ISSN-L
0007-1161
Statut éditorial
Publié
Date de publication
03/2012
Peer-reviewed
Oui
Volume
96
Numéro
3
Pages
337-340
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
Extension of retinoblastoma cells into the posterior chamber is a criterion for group E according to the international classification of intraocular retinoblastoma. Currently, the anterior extension of retinoblastoma is based on the presence of tumour cells in the anterior chamber assessed by biomicroscopy.
To determine the value of ultrasound biomicroscopy (UBM) in the assessment of posterior chamber involvement in advanced retinoblastoma.
Retrospective review of all retinoblastoma cases enucleated at the Jules Gonin Eye Hospital from January 1996 to December 2009 for which UBM (35 MHz) evaluation was available. The patients' records were reviewed for patient and tumour features and histopathological findings. UBM findings were compared with histopathological features.
UBM documentation was available in 31 cases. Retinoblastoma was detected by UBM in the posterior chamber in 18 cases and was absent in 13 cases while histopathological analysis demonstrated its presence in the posterior chamber in 22 cases and its absence in 9 cases. Among the 18 UBM-positive cases, 7 had biomicroscopic detectable involvement of the anterior chamber. There was a significant correlation between echodensities consistent with retinoblastoma on UBM in the posterior chamber and histopathological tumorous involvement of the posterior chamber (p=0.0001). The sensitivity of UBM in the assessment of posterior chamber invasion by retinoblastoma was 81% and the specificity was 100%.
In selected cases of advanced retinoblastoma, UBM appears to represent a valuable tool in the precise evaluation of anterior extension of disease, with good sensitivity and specificity for the assessment of posterior chamber involvement. UBM may provide useful criteria governing the indication for enucleation.

Mots-clé
Anterior Eye Segment/diagnostic imaging, Anterior Eye Segment/pathology, Child, Preschool, Eye Enucleation, Female, Humans, Male, Microscopy, Acoustic, Neoplasm Invasiveness/diagnostic imaging, Posterior Eye Segment/pathology, Posterior Eye Segment/ultrastructure, Reproducibility of Results, Retinal Neoplasms/diagnostic imaging, Retinal Neoplasms/pathology, Retinal Neoplasms/surgery, Retinoblastoma/diagnostic imaging, Retinoblastoma/pathology, Retinoblastoma/surgery, Retrospective Studies, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
18/01/2018 17:06
Dernière modification de la notice
20/08/2019 13:26
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