Genomic changes underlying host specialization in the bee gut symbiont Lactobacillus Firm5.

Détails

ID Serval
serval:BIB_37C4AFA6D4D6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genomic changes underlying host specialization in the bee gut symbiont Lactobacillus Firm5.
Périodique
Molecular ecology
Auteur(s)
Ellegaard K.M., Brochet S., Bonilla-Rosso G., Emery O., Glover N., Hadadi N., Jaron K.S., van der Meer J.R., Robinson-Rechavi M., Sentchilo V., Tagini F., Engel P.
Collaborateur(s)
SAGE class 2016-17
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Statut éditorial
Publié
Date de publication
05/2019
Peer-reviewed
Oui
Volume
28
Numéro
9
Pages
2224-2237
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Bacteria that engage in long-standing associations with particular hosts are expected to evolve host-specific adaptations that limit their capacity to thrive in other environments. Consistent with this, many gut symbionts seem to have a limited host range, based on community profiling and phylogenomics. However, few studies have experimentally investigated host specialization of gut symbionts and the underlying mechanisms have largely remained elusive. Here, we studied host specialization of a dominant gut symbiont of social bees, Lactobacillus Firm5. We show that Firm5 strains isolated from honey bees and bumble bees separate into deep-branching host-specific phylogenetic lineages. Despite their divergent evolution, colonization experiments show that bumble bee strains are capable of colonizing the honey bee gut. However, they were less successful than honey bee strains, and competition with honey bee strains completely abolished their colonization. In contrast, honey bee strains of divergent phylogenetic lineages were able to coexist within individual bees. This suggests that both host selection and interbacterial competition play important roles in host specialization. Using comparative genomics of 27 Firm5 isolates, we found that the genomes of honey bee strains harbour more carbohydrate-related functions than bumble bee strains, possibly providing a competitive advantage in the honey bee gut. Remarkably, most of the genes encoding carbohydrate-related functions were not conserved among the honey bee strains, which suggests that honey bees can support a metabolically more diverse community of Firm5 strains than bumble bees. These findings advance our understanding of the genomic changes underlying host specialization.
Mots-clé
Genetics, Ecology, Evolution, Behavior and Systematics, adaptation, bioinformatics/phyloinformatics, community ecology, genomics/proteomics, microbial biology, molecular evolution
Pubmed
Web of science
Création de la notice
20/03/2019 10:48
Dernière modification de la notice
20/08/2019 13:26
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