More than just proliferation: Myc function in stem cells.

Détails

ID Serval
serval:BIB_37950
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
More than just proliferation: Myc function in stem cells.
Périodique
Trends in Cell Biology
Auteur(s)
Murphy M.J., Wilson A., Trumpp A.
ISSN
0962-8924 (Print)
ISSN-L
0962-8924
Statut éditorial
Publié
Date de publication
2005
Volume
15
Numéro
3
Pages
128-137
Langue
anglais
Résumé
Adult stem cells are essential to maintain regenerative tissues such as skin epidermis, gastrointestinal mucosa or the hematopoietic system. Recent studies in mice suggest that the transcription factor and oncoprotein c-Myc has unexpected functions during both self-renewal and the differentiation of stem and early progenitor cells, particularly in interactions between stem cells and the local microenvironment or "niche". By incorporating recent findings on Myc and hematopoietic stem cells we propose a model in which "resting" hematopoietic stem cells are "activated" to self-renew and to differentiate at the interface between the niche and non-niche microenvironments.
Mots-clé
Animals, Bone Marrow Cells/cytology, Bone Marrow Cells/metabolism, Cell Differentiation, Cell Lineage, Cell Proliferation, Embryo, Mammalian/cytology, Embryo, Nonmammalian, Epidermis/metabolism, Gastrointestinal Tract/pathology, Hematopoietic Stem Cells/cytology, Humans, Mice, Models, Biological, Neural Crest/cytology, Proto-Oncogene Proteins c-myc/physiology, Skin/metabolism, Stem Cells/cytology, Stem Cells/metabolism, Xenopus
Pubmed
Web of science
Création de la notice
19/11/2007 12:36
Dernière modification de la notice
20/08/2019 13:26
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