The protooncogene MYC can break B cell tolerance.

Détails

ID Serval
serval:BIB_37931
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The protooncogene MYC can break B cell tolerance.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Refaeli Y., Field K.A., Turner B.C., Trumpp A., Bishop J.M.
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
2005
Volume
102
Numéro
11
Pages
4097-4102
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Résumé
The protooncogene MYC has been implicated in both the proliferation and programmed cell death of lymphoid cells, and in the genesis of lymphoid tumors. Here, we report that overexpression of MYC, as found in many lymphomas, can break immune tolerance. Mice that would otherwise be tolerant to a transgenic autoantigen mounted an immune response to the antigen if MYC was vigorously expressed in the B cell lineage. The responsive B cells converted to an activated phenotype and produced copious amounts of autoantibody that engendered immune complex disease of the kidney. MYC was required to both establish and maintain the breach of tolerance. These effects may be due to the ability of MYC to serve as a surrogate for cytokines. We found that the gene could mimic the effects of cytokines on both B cell proliferation and survival and, indeed, was required for those effects. These findings demonstrate a critical role for MYC in the response of B cells to antigen and expand the potential contributions of MYC to the genesis of lymphomas.
Mots-clé
Animals, Autoantibodies/immunology, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Cell Division/immunology, Cytokines/immunology, Cytokines/metabolism, Immune Tolerance/genetics, Immune Tolerance/immunology, Mice, Mice, Transgenic, Proto-Oncogene Proteins c-myc/genetics, Proto-Oncogene Proteins c-myc/immunology, Receptors, Antigen, B-Cell/genetics, Receptors, Antigen, B-Cell/immunology, Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 13:36
Dernière modification de la notice
08/05/2019 17:06
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