Potential value of biliary CEA assay in early detection of colorectal adenocarcinoma liver metastases.

Details

Serval ID
serval:BIB_377D35B3B778
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Potential value of biliary CEA assay in early detection of colorectal adenocarcinoma liver metastases.
Journal
European Journal of Surgical Oncology
Author(s)
Frikart L., Fournier K., Mach J.P., Givel J.C.
ISSN
0748-7983 (Print)
ISSN-L
0748-7983
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
21
Number
3
Pages
276-279
Language
english
Abstract
Elevation of the biliary CEA level in patients with liver metastases from colorectal carcinoma has been reported. The aim of this study is to determine the potential value of biliary CEA assay in the early detection of liver metastases. Biliary and serum CEA levels were determined in patients operated on for a colorectal cancer and in control groups. Among 13 patients with liver metastases from colorectal carcinomas, biliary CEA levels were markedly elevated (> 40 ng/ml) in nine, moderately elevated (5-40 ng/ml) in two and normal (arbitrarily defined as < 5 ng/ml) in two. Of 28 patients with primary colorectal carcinoma without detectable hepatic secondaries, three had marked CEA elevation in the bile, 10 had moderate CEA elevation and 15 had normal levels. Among nine patients with non-malignant hepatobiliary pathology, there was one marked biliary CEA elevation, one moderate elevation and seven normal levels. None of the 13 individuals with no identified hepatobiliary pathology had elevated biliary CEA levels. The follow-up of patients with a primary colorectal tumour, no evidence of hepatic secondaries and a biliary CEA elevation is of particular interest. If subsequent appearance of liver metastases is found in such cases, intra-operative biliary CEA assay could be considered a valuable diagnostic test. Further studies will then have to prove the possible benefit of a specific treatment for this group of patients.
Keywords
Adenocarcinoma/immunology, Adenocarcinoma/secondary, Aged, Aged, 80 and over, Carcinoembryonic Antigen/blood, Colorectal Neoplasms/immunology, Colorectal Neoplasms/pathology, Female, Humans, Liver Neoplasms/immunology, Liver Neoplasms/secondary, Male, Middle Aged, Neoplasms, Multiple Primary/immunology, Neoplasms, Second Primary/immunology, Predictive Value of Tests
Pubmed
Create date
28/01/2008 8:56
Last modification date
20/08/2019 13:25
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