Portal vein embolization with N-butyl cyanoacrylate before partial hepatectomy in patients with hepatocellular carcinoma and underlying cirrhosis or advanced fibrosis.

Détails

ID Serval
serval:BIB_37745
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Portal vein embolization with N-butyl cyanoacrylate before partial hepatectomy in patients with hepatocellular carcinoma and underlying cirrhosis or advanced fibrosis.
Périodique
Journal of vascular and interventional radiology : JVIR
Auteur(s)
Denys A., Lacombe C., Schneider F., Madoff D.C., Doenz F., Qanadli S.D., Halkic N., Sauvanet A., Vilgrain V., Schnyder P.
ISSN
1051-0443
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
16
Numéro
12
Pages
1667-74
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
PURPOSE: To describe the safety, complications, and liver regeneration associated with the left liver after embolization of the right portal vein (PV) in patients with hepatocellular carcinoma (HCC) developed in the setting of advanced liver fibrosis and cirrhosis. MATERIALS AND METHODS: Forty patients (31 men, nine women; mean age, 62 years) with HCC underwent PV embolization over a 4-year period. Embolization was performed from a left PV percutaneous access with use of n-butyl cyanoacrylate (NBCA) mixed with iodized oil. Computed tomography (CT) volumetry was performed before and 1 month after PV embolization to measure the left lobe volume as well as the functional liver ratio defined by the ratio between the left lobe and the total liver volume minus tumoral volume. PV pressure and liver enzyme levels were compared before and 1 month after the procedure and complications were registered. Factors potentially affecting regeneration (age, sex, diabetes, chemoembolization, functional liver ratio before PV embolization, and Knodell histologic score) were evaluated by one-way and stepwise regression analysis. RESULTS: PV embolization could be achieved successfully in all cases. Two patients had partial PV thrombosis on the 1-month follow-up CT and two patients developed transient ascites after PV embolization. The left lobe volume increase was 41% +/- 32% after PV embolization and the functional liver ratio increased from 28% +/- 10% to 36% +/- 10% (P < .0001). Hypertrophy of the left lobe was greater in patients with a low functional liver ratio before PV embolization and those with an F3 fibrosis score. Other factors had no influence on left lobe regeneration. CONCLUSION: PV embolization with use of NBCA is feasible in patients with advanced fibrosis and cirrhosis. Hypertrophy of the left lobe of the liver after PV embolization has a statistically significant correlation with lower functional liver ratio and lower degrees of fibrosis.
Mots-clé
Adult, Aged, Carcinoma, Hepatocellular, Contrast Media, Cyanoacrylates, Embolization, Therapeutic, Enbucrilate, Feasibility Studies, Female, Humans, Hypertrophy, Iodized Oil, Liver, Liver Cirrhosis, Liver Neoplasms, Male, Middle Aged, Multivariate Analysis, Portal Vein, Radiography, Interventional, Retrospective Studies, Tomography, X-Ray Computed, Treatment Outcome
Pubmed
Web of science
Création de la notice
19/11/2007 13:35
Dernière modification de la notice
03/03/2018 16:05
Données d'usage