Possible correlation between low antigenic drift of A(H1N1) influenza viruses and induction of HI antibodies.

Détails

ID Serval
serval:BIB_37426E1070BC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Possible correlation between low antigenic drift of A(H1N1) influenza viruses and induction of HI antibodies.
Périodique
European Journal of Epidemiology
Auteur(s)
Iorio A.M., Zei T., Neri M., Alatri A.
ISSN
0393-2990 (Print)
ISSN-L
0393-2990
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
12
Numéro
6
Pages
589-594
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
This study examined whether, during a seven-year period of low A(H1N1) influenza virus antigenic drift (1988-1989 and 1994-1995, winters), humoral antibody response of elderly volunteers to influenza vaccines could suggest a lack of antibody pressure for drift. In all the years studied A/Taiwan/1/86, the A(H1N1) vaccine component, had a low ability to induce protective hemagglutination-inhibiting (HI) antibody titres (> or = 1:40). However a similar low immunogenicity was found for some of the different A(H3N2) strain variants of influenza virus, co-circulating in the same period and showing a regular extent of antigenic variations. Although our data could be at least in part explained by the type of study population (elderly and repeatedly vaccinated), postepidemic serological studies did not evidence a consistently lower ability in mounting protective immune response in elderly people as compared with younger against the influenza strains studied. Therefore, our present results did not exclude a true low immunogenicity of A/Taiwan and of some A(H3N2) influenza strains, circulating in the winters examined. This suggests that, besides the necessity to evade prior immunity, additional factors could influence the frequency of influenza viruses antigenic drifts.
Mots-clé
Aged, Aged, 80 and over, Antibodies, Viral/biosynthesis, Antigenic Variation/genetics, Antigens, Viral/genetics, Antigens, Viral/immunology, Female, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus/genetics, Humans, Influenza A Virus, H1N1 Subtype, Influenza A virus/genetics, Influenza A virus/immunology, Influenza Vaccines/administration & dosage, Influenza, Human/immunology, Influenza, Human/prevention & control, Male, Middle Aged, Vaccination, Vaccines, Inactivated/administration & dosage
Pubmed
Web of science
Création de la notice
14/02/2013 13:44
Dernière modification de la notice
03/03/2018 16:04
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