A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response.

Détails

ID Serval
serval:BIB_370F130E0147
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response.
Périodique
Vaccine
Auteur(s)
Miconnet I., Pantaleo G.
ISSN
0264-410X (Print)
ISSN-L
0264-410X
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
26
Numéro
32
Pages
4006-4014
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
A strategy to improve the immunogenicity of candidate vaccines is to trigger the innate immune system. Triggering of CD40 at the surface of dendritic cells (DC) is essential in the induction of an efficient immune response. Although CD40 agonist antibodies have been shown to be potent inducers of immune responses in experimental models, serious safety concerns have been raised for their use in humans. In addition, the production of soluble functional CD40 ligand has been challenging and the soluble form existing so far is not developed anymore. Here, we have evaluated the potency of a new soluble form of hexameric CD40 ligand (sCD40L) to serve as an adjuvant for anti-viral T cell responses. sCD40L was able to activate human DC and to enhance virus-specific memory T cell responses. These results demonstrate that this soluble form of CD40 ligand may serve as an adjuvant for T cell response and thus provide the rationale for its potential use in T cell based vaccine strategies.
Mots-clé
CD40 Ligand/chemistry, CD40 Ligand/pharmacology, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/drug effects, Cell Line, Cell Proliferation, Cytokines/immunology, Dendritic Cells/drug effects, Humans, Immunologic Memory/drug effects, Leukocytes, Mononuclear/cytology, Silver/metabolism, T-Lymphocytes, Cytotoxic/drug effects, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Création de la notice
21/01/2009 16:26
Dernière modification de la notice
03/03/2018 16:03
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