Contribution of connexins to the function of the vascular wall

Détails

Ressource 1Télécharger: serval:BIB_36FD7572AFED.P001 (652.12 [Ko])
Etat: Public
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ID Serval
serval:BIB_36FD7572AFED
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Contribution of connexins to the function of the vascular wall
Périodique
Cardiovascular Research
Auteur(s)
Haefliger  J. A., Nicod  P., Meda  P.
ISSN
0008-6363 (Print)
Statut éditorial
Publié
Date de publication
05/2004
Volume
62
Numéro
2
Pages
345-56
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: May 1
Résumé
Gap junction channels provide an enclosed conduit for direct exchanges of signalling molecules, including ions and small metabolites between cells. This system of communication allows cells to monitor the functional state of their neighbours, and is rapidly modulated to continuously adapt to the immediate needs of groups of coupled cells. In the major arteries, endothelial cells may express three connexins isotypes, namely Connexin 37 (Cx37), Cx40 and Cx43, whereas the underlying smooth muscle cells may express Cx37, Cx40, Cx43 and Cx45. Moreover, myoendothelial gap junctions have also been shown to be involved in the regulation of vascular tone. This review highlights the regulation of vessel connexins in response to injury, as observed during experimental hypertension or wound repair, as well as the consequences of loss of one connexin in different transgenic null mice. In view of the major endocrine role of the kidney in the control of blood pressure, we also discuss the distribution of connexins in the kidney vasculature. Cx40 is present between endothelial cells of vessels and glomeruli, as well as between renin-secreting cells, the modified smooth muscle cells which form the wall of the terminal part of afferent arterioles. Modulation of Cx40 expression in a model of renin-dependent hypertension suggests that this connexin may be implicated in the function of renin-secreting cells. Finally, to address the possible regulation of connexin expression by fluid pressure, we summarize the effects of elevated transmural urine pressure on bladder Cx43 expression.
Mots-clé
Animals Cell Communication Connexins/*metabolism Endothelium, Vascular/*metabolism Humans Hypertension/*metabolism/physiopathology Ion Channels/*metabolism Kidney/blood supply Muscle, Smooth, Vascular/*metabolism/physiopathology Stress, Mechanical Urinary Bladder/metabolism/physiopathology Wound Healing
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:47
Dernière modification de la notice
25/09/2019 7:08
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