Insuline, monoxyde d'azote et systeme nerveux sympathique: au carrefour de l'homeostasie metabolique et cardiovasculaire. [Insulin, nitric oxide and the sympathetic nervous system: from crossroads to metabolic and cardiovascular homeostasis]
Details
Serval ID
serval:BIB_35F845C79898
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Insuline, monoxyde d'azote et systeme nerveux sympathique: au carrefour de l'homeostasie metabolique et cardiovasculaire. [Insulin, nitric oxide and the sympathetic nervous system: from crossroads to metabolic and cardiovascular homeostasis]
Journal
Revue Médicale de la Suisse Romande
ISSN
0035-3655 (Print)
Publication state
Published
Issued date
10/2004
Volume
124
Number
10
Pages
635-8
Notes
English Abstract
Journal Article
Review --- Old month value: Oct
Journal Article
Review --- Old month value: Oct
Abstract
Epidemiological studies demonstrate an association between insulin resistance, hypertension and cardiovascular morbidity. Over the past decade, evidence has accumulated indicating that short-term insulin administration, in addition to its metabolic effects, also has important cardiovascular actions. The sympathetic nervous system and the L-arginine-nitric oxide pathway have emerged as central players in the mediation of insulin's cardiovascular actions. The underlying mechanisms and the factors that may govern the interaction between insulin and these two major cardiovascular regulatory systems have been studied extensively in healthy people and insulin-resistant subjects. Here we summarize the current understanding and gaps in knowledge on insulin's cardiovascular actions in humans, and discuss possible pathophysiological consequences of their alteration. Based on recent new insight, we propose that a genetic and/or acquired defect of nitric oxide synthesis could represent a central defect triggering many of the metabolic, vascular and sympathetic abnormalities characteristic of insulin-resistant states, all of which may predispose to cardiovascular disease.
Keywords
Cardiovascular Diseases/*etiology/physiopathology
Homeostasis
Humans
Hypertension/*complications/physiopathology
*Insulin Resistance
Nitric Oxide/*pharmacology
Risk Factors
Sympathetic Nervous System/*physiology
Pubmed
Create date
25/01/2008 13:44
Last modification date
20/08/2019 13:23