IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.

Détails

ID Serval
serval:BIB_3599BB2EC5FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.
Périodique
Immunity
Auteur(s)
Launois P., Maillard I., Pingel S., Swihart K.G., Xénarios I., Acha-Orbea H., Diggelmann H., Locksley R.M., MacDonald H.R., Louis J.A.
ISSN
1074-7613 (Print)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
6
Numéro
5
Pages
541-549
Langue
anglais
Résumé
BALB/c mice develop aberrant T helper 2 (Th2) responses and suffer progressive disease after infection with Leishmania major. These outcomes depend on the production of interleukin-4 (IL-4) early after infection. Here we demonstrate that the burst of IL-4 mRNA, peaking in draining lymph nodes of BALB/c mice 16 hr after infection, occurs within CD4+ T cells that express V beta 4 V alpha 8 T cell receptors. In contrast to control and V beta 6-deficient BALB/c mice, V beta 4-deficient BALB/c mice were resistant to infection, demonstrating the role of these cells in Th2 development. The early IL-4 response was absent in these mice, and T helper 1 responses occurred following infection. Recombinant LACK antigen from L. major induced comparable IL-4 production in V beta 4 V alpha 8 CD4+ cells. Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of V beta 4 V alpha 8 CD4+ T cells after cognate interaction with a single antigen from this complex organism.
Mots-clé
Animals, Antigens, CD4/analysis, Antigens, CD4/genetics, Antigens, Protozoan/pharmacology, Cell Differentiation/immunology, Disease Susceptibility, Female, Immunity, Innate, Interleukin-4/biosynthesis, Interleukin-4/genetics, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Mice, Mice, Inbred BALB C, Protozoan Proteins/pharmacology, RNA, Messenger/biosynthesis, Receptors, Antigen, T-Cell, alpha-beta/immunology, Receptors, Antigen, T-Cell, alpha-beta/metabolism, Recombinant Proteins/pharmacology, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism, Th2 Cells/cytology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 13:23
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