Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.

Details

Serval ID
serval:BIB_35894D4850A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.
Journal
Journal of Neuroimmunology
Author(s)
Raoul W., Keller N., Rodéro M., Behar-Cohen F., Sennlaub F., Combadière C.
ISSN
0165-5728 (Print)
ISSN-L
0165-5728
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
198
Number
1-2
Pages
56-61
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
We recently showed that subretinal CX3CR1-dependent microglial cell (MC) accumulation may lead to age-related macular degeneration. The fate of MC after engulfing retinal debris is poorly understood. Severe photoreceptor degeneration was observed 40days after exposure to bright light in CX3CR1-deficient but not control mice, and more MCs accumulated in the subretinal space of the former than the latter. To study the fate of subretinal MCs in CX3CR1 competent animals, we used a dystrophic rat model in which abundant subretinal MC accumulation is observed secondary to retinal degeneration. In dystrophic rats, MCs containing rhodopsin or rod outer segment (ROS) debris were found outside the outer retina at sites suggesting choroidal and ciliary egress. In conclusion, our data indicate that MC accumulation at injury sites is independent of CX3CR1 and precedes photoreceptor degeneration. The ectopic presence of rhodopsin-positive MCs suggests that CX3CR1 participates in MC egress from the outer retina.
Keywords
Animals, Cell Movement/physiology, Gene Expression Regulation, Green Fluorescent Proteins/genetics, Green Fluorescent Proteins/metabolism, Light/adverse effects, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microglia/physiology, Microglia/ultrastructure, Microscopy, Electron, Transmission/methods, Phagocytes/physiology, Phagocytes/ultrastructure, Phagocytosis/genetics, Photoreceptor Cells/metabolism, Photoreceptor Cells/ultrastructure, Receptors, Chemokine/deficiency, Receptors, Chemokine/physiology, Retina/cytology, Retinal Degeneration/etiology, Retinal Degeneration/pathology, Rhodopsin/metabolism, Statistics, Nonparametric, Time Factors
Pubmed
Web of science
Create date
26/08/2013 15:07
Last modification date
20/08/2019 13:23
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