Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?

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State: Public
Version: Final published version
Serval ID
serval:BIB_3553A9A6B3FD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?
Journal
International Journal of Molecular Sciences
Author(s)
Arnould T., Michel S., Renard P.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
16
Number
8
Pages
18224-18251
Language
english
Notes
Publication types: Review ; review-article Identifiant PubMed Central: PMC4581242
Abstract
Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuring the maintenance of quality control of mitochondria, allowing functional integrity of the mitochondrial proteome. When misfolded proteins or unassembled complexes accumulate beyond the folding capacity, it leads to alteration of proteostasis, damages, and organelle/cell dysfunction. Extensively studied for the ER, it was recently reported that this kind of signaling for mitochondrion would also be able to communicate with the nucleus in response to impaired proteostasis. The mitochondrial unfolded protein response (UPR(mt)) is activated in response to different types and levels of stress, especially in conditions where unfolded or misfolded mitochondrial proteins accumulate and aggregate. A specific UPR(mt) could thus be initiated to boost folding and degradation capacity in response to unfolded and aggregated protein accumulation. Although first described in mammals, the UPR(mt) was mainly studied in Caenorhabditis elegans, and accumulating evidence suggests that mechanisms triggered in response to a UPR(mt) might be different in C. elegans and mammals. In this review, we discuss and integrate recent data from the literature to address whether the UPR(mt) is relevant to mitochondrial homeostasis in mammals and to analyze the putative role of integrated stress response (ISR) activation in response to the inhibition of mtDNA expression and/or accumulation of mitochondrial mis/unfolded proteins.
Keywords
DNA, Mitochondrial/genetics, DNA, Mitochondrial/metabolism, Mitochondria/genetics, Mitochondria/metabolism, Mitochondrial Proteins/genetics, Mitochondrial Proteins/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
25/07/2016 8:19
Last modification date
20/08/2019 13:22
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