Pattern of expression of the transcription factor Krox-20 in mouse hair follicle
Details
Serval ID
serval:BIB_3507C23F6DE5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pattern of expression of the transcription factor Krox-20 in mouse hair follicle
Journal
Mechanisms of Development
ISSN
0925-4773 (Print)
Publication state
Published
Issued date
09/2000
Volume
96
Number
2
Pages
215-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
We examined the pattern of expression in hair follicles of the transcription factor gene Krox-20. During embryogenesis, Krox-20 is first expressed in the upper portion of the hair bud, then in the hair canal, in the sebaceous glands and in the outer root sheath. In the mature follicles, Krox-20, like Shh and TGFbetaRII, is also expressed in a sub-population of matrix keratinocytes located in a ring-like fashion in vibrissal follicles and clustered on one side of the papilla in pelage follicles. This polarized pattern rotates around the papilla as a result of sequential gene expression by individual groups of matrix cells. This peculiar pattern is not linked to follicle angling.
Keywords
Animals
Base Sequence
DNA Primers/genetics
DNA-Binding Proteins/*genetics/metabolism
Early Growth Response Protein 2
Gene Expression Regulation, Developmental
Genes, Immediate-Early
Hair Follicle/*embryology/*metabolism
Immunohistochemistry
In Situ Hybridization
Lac Operon
Mice
Mice, Transgenic
Transcription Factors/*genetics/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 9:41
Last modification date
20/08/2019 14:22