Pattern of expression of the transcription factor Krox-20 in mouse hair follicle

Details

Serval ID
serval:BIB_3507C23F6DE5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pattern of expression of the transcription factor Krox-20 in mouse hair follicle
Journal
Mechanisms of Development
Author(s)
Gambardella  L., Schneider-Maunoury  S., Voiculescu  O., Charnay  P., Barrandon  Y.
ISSN
0925-4773 (Print)
Publication state
Published
Issued date
09/2000
Volume
96
Number
2
Pages
215-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
We examined the pattern of expression in hair follicles of the transcription factor gene Krox-20. During embryogenesis, Krox-20 is first expressed in the upper portion of the hair bud, then in the hair canal, in the sebaceous glands and in the outer root sheath. In the mature follicles, Krox-20, like Shh and TGFbetaRII, is also expressed in a sub-population of matrix keratinocytes located in a ring-like fashion in vibrissal follicles and clustered on one side of the papilla in pelage follicles. This polarized pattern rotates around the papilla as a result of sequential gene expression by individual groups of matrix cells. This peculiar pattern is not linked to follicle angling.
Keywords
Animals Base Sequence DNA Primers/genetics DNA-Binding Proteins/*genetics/metabolism Early Growth Response Protein 2 Gene Expression Regulation, Developmental Genes, Immediate-Early Hair Follicle/*embryology/*metabolism Immunohistochemistry In Situ Hybridization Lac Operon Mice Mice, Transgenic Transcription Factors/*genetics/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 8:41
Last modification date
20/08/2019 13:22
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